Fig. 5. Ectopic neurons form even when cell proliferation is inhibited in neural precursors. Embryos at the early gastrula stage were treated with hydroxyurea and aphidicolin (HUA) to inhibit cell division (Harris and Hartenstein, 1991) and assayed for XIF3 at the tailbud stage. XIF3 staining is somewhat punctate along the neural tube of uninjected and control xRARα2∆h*d/xRXRβ- coinjected embryos, probably reflecting the HUA treatment. Coinjection of xRARα2/xRXRβ, however, generates ectopic neurons both in untreated and HUA-treated embryos (arrowheads). It is therefore likely that the ectopic neurons do not form through increased proliferation of neural precursors.
Image published in: Sharpe CR and Goldstone K (1997)
Copyright © 1997. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| prph.L | nef4, peripherin, XIF3 | X. laevis | Throughout NF stage 26 | brain nervous system spinal cord |
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