Xenbase Release v3.3

· New morpholino feature added
· New genome builds and gene models
· Transgenic nomenclature guidelines
· New genome editing links added
· GEISHA (chicken) orthology imported into database and added to gene pages
· 10,000+ PubMed Central (PMC) article images added to Xenbase
· OMIM disorders associated with Xenopus genes added to gene pages

Check out the Xenopus antibody database and improved genome browser.

Please send us comments and feedback.

NIH launches new initiative to study the basis of human birth defects

There are some important funding opportunities at the NIH in which the utility of Xenopus for research in human congenital disorders is ideal.

Epigenome reference map track hub

Coming Soon!

Over 50 genome browser tracks soon to be released for the Xenopus tropicalis v7.1 and v8.0 assemblies. These ChIP-sequencing tracks cover eight histone modifications, RNA polymerase II (RNAPII) and the enhancer-binding protein p300 during Xenopus tropicalis development from blastula to larval stages.

Highly efficient gene knockout by injection of TALEN mRNAs into oocytes and host transfer in X. laevis

Nakajima & Yaoita describe in the journal, Biology Open, a combination of oocyte injection of TALEN mRNA injection with oocyte host transfer enhances effectiveness of gene modification.

Recent genome-wide analyses in Xenopus

We highlight a collection of recent articles detailing genome-wide analysis in Xenopus using high-throughput ChIP-seq and RNA-seq methods.

Check them out!

Cell and Developmental Biology of Xenopus: 2015 Course at Cold Spring Harbor

Gene Discovery and Disease

April 9-21, 2015

Scholarships available! Application deadline February 23, 2015

Instructors:

Mustafa Khokha, Yale University

Karen Liu, King's College London, UK

Cytokinesis signaling visualized in vitro, using Xenopus cell-free system

Nguyen et al. reconstituted cytokinesis protein organization outside living cells, using a system derived from Xenopus egg extracts. This article is available from Science.

Developmental Biology: Xenopus Issue

Submissions to a special issue of the journal Developmental Biology entitled: Modeling Human Development and Disease in Xenopus will open on August 1, 2014. Manuscripts can be submitted until November 1 2014, although earlier is better. Peer review must be completed and manuscript disposition determined no later than March 15th 2015, for publication in late spring.

New Xenopus Genome Assemblies

The Xenopus Genome Consortium has released the newest laevis v7.1 and tropicalis v8.0 assemblies.

2014 Xenopus White Paper

Representatives of the research community have released the 2014 Xenopus White Paper summarizing strategic resource development.
 

Download 2014 Xenopus White Paper

Xenbase Release v3.3

· New morpholino feature added
· New genome builds and gene models
· Transgenic nomenclature guidelines
· New genome editing links added
· GEISHA (chicken) orthology imported into database and added to gene pages
· 10,000+ PubMed Central (PMC) article images added to Xenbase
· OMIM disorders associated with Xenopus genes added to gene pages

Check out the Xenopus antibody database and improved genome browser.

Please send us comments and feedback.