Xenbase Release 3.2

· New genome editing links added
· GEISHA (chicken) orthology imported into database and added to gene pages
· 10,000+ PubMed Central (PMC) article images added to Xenbase
· OMIM disorders associated with Xenopus genes added to gene pages

Check out the new Xenopus antibody database and improved genome browser.

Please send us comments and feedback.

Richard Harland elected to membership of the National Academy of Sciences; awarded the SDB 2014 Conklin Medal

Dr. Harland found that BMP antagonists are fundamental for the patterning of germ layers. His research expands our knowledge of neural induction/patterning, FGF signaling, planar cell polarity, and developmental control of RNA splicing.

Timothy Mitchison and Andrew Murray elected to membership of the National Academy of Sciences

Dr. Mitchison and Dr. Murray's seminal research using Xenopus egg cell extracts greatly contributes to our understanding of the cell cycle progression and cell division.

Quantitative proteomics of Xenopus laevis embryos

Expression kinetics of nearly 4000 proteins during early development.

Sun et al. report the largest developmental proteomic dataset for any animal.

Sp8 regulates inner ear development

Chung et al. published in The Proceedings of the National Academy of Sciences that the eclipse mutant of Xenopus tropicalis has alterations in the sp8 gene locus. These tadpoles had decreased startle reflexes and altered swimming balance resulting from faulty embryonic inner ear development.

A new Xenopus model for Urofacial Syndrome

Roberts et al. identified and knocked down the Xenopus orthologue of human HPSE2: establishing for the first time an in vivo vertebrate model for urofacial syndrome (UFS). This is the first study to shed light on the mechanisms underpinning the clinical features of UFS.

PCP and Septins Compartmentalize Cortical Actomyosin to Direct Collective Cell Movement

Shindo & Wallingford, published in the journal, Science that planar cell polarity (PCP) proteins control convergent extension by exploiting an evolutionarily ancient function of the septin cytoskeleton.

(shown: phospho-myosin light chain in embryonic notochord cell membranes)

Developmental Biology: Xenopus Issue

Submissions to a special issue of the journal Developmental Biology entitled: Modeling Human Development and Disease in Xenopus will open on August 1, 2014. Manuscripts can be submitted until November 1 2014, although earlier is better. Peer review must be completed and manuscript disposition determined no later than March 15th 2015, for publication in late spring.

Christopher Wylie and Janet Heasman Honored with SDB Lifetime Achievement Award

Wylie and Heasman are being honored for their outstanding and sustained research and mentoring contributions to the field of developmental biology.

15th International Xenopus Meeting

Save the date!

The biennial gathering of Xenopus biomedical researchers:

August 24th - 28th, 2014 in Asilomar, CA

Abstract submissions are now being accepted until Jun 10.

Conference registration is now open until July 24.

Click here to go to the meeting website.

New Xenopus Genome Assemblies

The Xenopus Genome Consortium has released the newest laevis v7.1 and tropicalis v8.0 assemblies.

2014 Xenopus White Paper

Representatives of the research community have released the 2014 Xenopus White Paper summarizing strategic resource development.
 

Download 2014 Xenopus White Paper

Xenbase Release 3.2

· New genome editing links added
· GEISHA (chicken) orthology imported into database and added to gene pages
· 10,000+ PubMed Central (PMC) article images added to Xenbase
· OMIM disorders associated with Xenopus genes added to gene pages

Check out the new Xenopus antibody database and improved genome browser.

Please send us comments and feedback.