Xenopus tropicalis v10 genome

- available to BLAST

- view on JBrowse

Xenbase v4.12.1 Release

Included in the latest Xenbase release:

- Xenopus tropicalis genome v10 sequence and assembly

- GEO GSE visualization (view our tutorial video) 

Xenbase Tutorials: GEO Data Simple and Advanced Search

Please view the Xenbase tutorial videos for the simple and advanced search interface for Xenopus GEO datasets.

Added tutorial: Navigating a GSE page.

The Allied Genetics Conference 2020

Gaylord National Resort & Convention Center
Metro Washington, DC
April 22–26, 2020

Abstract deadline, Dec. 13, 2019

Early Registration deadline, Dec.20, 2019

The invited Xenopus speaker is John Wallingford (UT Austin, USA).

TAGC2020 website

Basal cells in Xenopus mucociliary epithelium

Haas et al. using Xenopus mucociliary epidermis, the mouse airway, and human airway basal cells demonstrate that wnt is necessary for cilia formation during differentiaion. In basal cells, wnt prevents specification of epithelial cell types by activating the master transcription factor, ΔN-Tp63 which is required to retain basal cell stemness during development. Published in Cell Reports.

The Epigenetic Control of Pluripotent Signal Competence

Gentsch et al. demonstrate that maternal pluripotency factors initiate epigeneic remodelling of thousands of regulatory elements on which signal mediators act to regionalise zygotic genome activity, specifying the three germ layers. Their discovery is a first step in understanding how proteins permit a cell type-specific signal response. Published in Nature Communications.

Single Amino Acid Change Underlies Distinct Roles of H2A.Z Subtypes in Human Syndrome

Greenberg et al. published in Cell their study of the developmental disorder, Floating-Harbor syndrome (FHS) caused by mutations in the chromatin remodelling gene, SRCAP which functions through H2A.Z.2-containing nucleosomes, regulating AT-rich enhancers.

Defining the vertebrate cardiac proteome

Federspiel et al. published in PLoS Biology their study identifying the core protein composition, complexes, and pathways in vertebrates from Xenopus to human heart. They reveal that each species shares a unique set of proteins with humans but not the other vertebrates studied.

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Xenopus tropicalis v10 genome

- available to BLAST

- view on JBrowse