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  • High variability of expression profiles of homeologous genes for Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus laevis

  • miR-182 Regulates Slit2-Mediated Axon Guidance by Modulating the Local Translation of a Specific mRNA

    Bellon et al. published in Cell Reports the role of microRNAs in mRNA-specific translation during axonal pathfinding of Xenopus laevis retinal ganglion cells (RGCs). They found that miR-182 targets cofilin-1 mRNA, silencing its translation. Slit2 rapidly relieves this repression without causing miR-182 degradation. Their data support a model where miR-182 reversibly gates the selection of certain mRNAs for fast translation depending on extrinsic cues.

    we investigate the local role of miRNAs in mRNA-specific translation during pathfinding of Xenopus laevis retinal ganglion cell (RGC) axons.
  • Leftward Flow Determines Laterality in Conjoined Twins

    Tisler et al. published in Current Biology their study of an enigmatic left-right defect in conjoined twins. Twins fused at the thorax: left twins are normal, laterality is disturbed in one-half of right twins due to insufficient suppression of the Nodal inhibitor, dand5.

  • GO: Gene Ontology terms on Xenbase

    Expanded representation of Gene Ontology (GO) terms associated with gene product function added to Xenopus gene pages.

    Look for the tab on gene summary pages...

  • Genome evolution in the allotetraploid frog Xenopus laevis

    Session et al. published in Nature describe the analysis of the subgenomes of the allotetraploid Xenopus laevis. The L subgenome more consistenly resembles the ancestral condition and the S subgenome is more disrupted by deletion and rearrangment.

  • Genesis Special Issue - Xenopus: Advances and Emerging Technologies

    Check out the January 2017 issue of Genesis highlighting current advances using Xenopus as a biomedical research model.

  • Gene Regulatory Networks White Paper 2016

    A “final” draft of the GRN white paper is in the works, but several people request that the current working white paper draft be made publicly available.

    This would allow everyone to refer to the white paper in grants or manuscripts. The GRN White Paper draft will be hosted on Xenbase.

    This current draft will eventually be replaced with the final 2016 version.

    Click here to download the draft of the GRN White Paper.

  • Updated Xenopus laevis genome annotation

    Gene Model Annotation 1.8.3 of the X. laevis 9.1 Genome Build

    The latest annotation of the X. laevis 9.1 genome is ready!  

    This release only includes updating the gene symbol of existing gene models.  

    The files for this annotation release, GFFs and FASTA, can be downloaded from the Xenbase FTP page, under the X. laevis genome assemblies and gene models category.

  • 2016 Xenopus White Paper

    Representatives of the research community have released the 2016 Xenopus White Paper summarizing strategic resource development.

    Download: Word Doc, PDF

    PIs: Please reference the White Paper in your NIH grant proposals and contact your program officers.

  • High variability of expression profiles of homeologous genes for Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus laevis


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