Quantitative Proteomics After Spinal Cord Injury

Lee-Liu et al. published in Molecular & Cellular Proteomics their study measuring the proteomic response in X. laevis after spinal cord injury (SCI).

SCI was induced at regerative and non-regenerative stages. They quantified a total of 6,384 proteins, with 172 showing significant differential expression in the regenerative stage and 240 in the nonregenerative stage, with an overlap of only 14 proteins.

Morpholino Side Effects

Gentsch et al. published in Developmental Cell highlight:

Brachyury KO and KD in frog equally affect phenotype-causing downstream genes.
Other transcriptional anomalies are unique to morpholino-based KDs and controls.
Morpholinos can trigger an innate immune response and off-target mis-splicing.
Optimization of KD conditions mitigates but does not eliminate these side effects.

Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo

Neural crest cells sense the stiffening in the extracellular matrix of the underlying mesoderm through integrin signalling, and undergo an epithelial-to-mesenchymal transition before starting their collective migration. Barriga et al published in Nature.

17th International Xenopus Conference

Save the date!

August 12-16, 2018.

Seattle, Washington, USA.

Abstracts now being accepted.

Early Registration: June 29, 2018.

Click here to go to the meeting website.

Society for Developmental Biology 77th Annual Meeting

Portland, OR USA

July 20-24, 2018

Registration now open.

Visit: https://www.sdbonline.org/2018mtg

2018 Xenopus Bioinformatics Workshop

Registration now open.

May 13-19, 2018

at the NXR at the MBL in Woods Hole, Massachusetts.

EctoMap

A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates. Plouhinec et al. published in PLoS Biology

Click here to go to EctoMap-lite.

The Zahn Drawings

A new developmental series for Xenopus, ‘the Zahn drawings’ and a complementary set of bright field photographs have been published in Development. These drawings provide researchers with views of the tadpole stages during cranial development, NF stage 22-50.

Quantitative Proteomics After Spinal Cord Injury

Lee-Liu et al. published in Molecular & Cellular Proteomics their study measuring the proteomic response in X. laevis after spinal cord injury (SCI).

SCI was induced at regerative and non-regenerative stages. They quantified a total of 6,384 proteins, with 172 showing significant differential expression in the regenerative stage and 240 in the nonregenerative stage, with an overlap of only 14 proteins.