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  • GO: Gene Ontology terms on Xenbase

    Expanded representation of Gene Ontology (GO) terms associated with gene product function added to Xenopus gene pages.

    Look for the tab on gene summary pages...

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  • Genesis Special Issue - Xenopus: Advances and Emerging Technologies

    Check out the January 2017 issue of Genesis highlighting current advances using Xenopus as a biomedical research model.

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  • High variability of expression profiles of homeologous genes for Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus laevis

    Michiue et al. published in Developmental Biology their detailed analysis of 415 genes involved in these key developmental signaling pathways in the allotetraploid frog.

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  • Congratulations to Professor Sir James Cuthbert Smith, FRS

    Professor Sir Jim Smith of The Francis Crick Institute was knighted in the Queen's New Year's Honours (2017) for services to medical research and science education.

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  • De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome (BAMS) and abrogate nasal development

    Gordon et al. report in Nature Genetics that missense mutations in the epigenetic regulator SMCHD1 mapping to the extended ATPase domain of the encoded protein cause BAMS in all 14 cases studied.

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  • Spinal cord regeneration in Xenopus laevis

    Edwards-Faret et al. describe in Nature Protols their methods for the husbandry of Xenopus laevis tadpoles and froglets and procedures to study spinal cord regeneration.

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  • Genome evolution in the allotetraploid frog Xenopus laevis

    Session et al. published in Nature describe the analysis of the subgenomes of the allotetraploid Xenopus laevis. The L subgenome more consistenly resembles the ancestral condition and the S subgenome is more disrupted by deletion and rearrangment.

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  • Gene Regulatory Networks White Paper 2016

    A “final” draft of the GRN white paper is in the works, but several people request that the current working white paper draft be made publicly available.

    This would allow everyone to refer to the white paper in grants or manuscripts. The GRN White Paper draft will be hosted on Xenbase.

    This current draft will eventually be replaced with the final 2016 version.

    Click here to download the draft of the GRN White Paper.

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  • Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors

    Kaminski et al. identified 4 factors that are able to directly reprogram fibroblasts into renal tubule cells.

    Induced renal tubule epithelial cells (iRECs) are similar to their native counterparts with respect to their transcriptional profile and morphological features, and can integrate into kidney organoids and decellularized kidneys.

    Their research is published in Nature Cell Biology.

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  • Mechanosensing is critical for axon growth in the developing brain

    Koser et al. identify mechanical signals as important regulators of axon pathfinding. In vitro, substrate stiffness determined growth patterns of Xenopus retinal ganglion cell axons. In vivo atomic force microscopy revealed a noticeable pattern of stiffness gradients in the embryonic brain.

    Published in Nature Neuroscience.

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  • Gene Regulatory Systems in Development

    March 27-30, 2017
    Parador de Carmona, Carmona, Spain
    Registration: March 1, 2017
    Abstracts: still being accepted

    The European Marie-Curie consortia DevCom and ZENCODE-ITN are jointly organising this conference. The topics of the conference will be single-cell profiling, chromatin dynamics, regulatory networks and evolutionary plasticity, with a profound role for Xenopus and zebrafish as model organisms.

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  • Updated Xenopus laevis genome annotation

    Gene Model Annotation 1.8.3 of the X. laevis 9.1 Genome Build

    The latest annotation of the X. laevis 9.1 genome is ready!  

    This release only includes updating the gene symbol of existing gene models.  

    The files for this annotation release, GFFs and FASTA, can be downloaded from the Xenbase FTP page, under the X. laevis genome assemblies and gene models category.

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  • 2016 Xenopus White Paper

    Representatives of the research community have released the 2016 Xenopus White Paper summarizing strategic resource development.

    Download: Word Doc, PDF

    PIs: Please reference the White Paper in your NIH grant proposals and contact your program officers.

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  • GO: Gene Ontology terms on Xenbase

    Expanded representation of Gene Ontology (GO) terms associated with gene product function added to Xenopus gene pages.

    Look for the tab on gene summary pages...

    Read More...
BLASTBLAST Xenopus

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