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  • Genome evolution in the allotetraploid frog Xenopus laevis

    Session et al. published in Nature describe the analysis of the subgenomes of the allotetraploid Xenopus laevis. The L subgenome more consistenly resembles the ancestral condition and the S subgenome is more disrupted by deletion and rearrangment.

    Read More...
  • Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors

    Kaminski et al. identified 4 factors that are able to directly reprogram fibroblasts into renal tubule cells.

    Induced renal tubule epithelial cells (iRECs) are similar to their native counterparts with respect to their transcriptional profile and morphological features, and can integrate into kidney organoids and decellularized kidneys.

    Their research is published in Nature Cell Biology.

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  • Mechanosensing is critical for axon growth in the developing brain

    Koser et al. identify mechanical signals as important regulators of axon pathfinding. In vitro, substrate stiffness determined growth patterns of Xenopus retinal ganglion cell axons. In vivo atomic force microscopy revealed a noticeable pattern of stiffness gradients in the embryonic brain.

    Published in Nature Neuroscience.

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  • Gene Regulatory Networks White Paper 2016

    A “final” draft of the GRN white paper is in the works, but several people request that the current working white paper draft be made publicly available.

    This would allow everyone to refer to the white paper in grants or manuscripts. The GRN White Paper draft will be hosted on Xenbase.

    This current draft will eventually be replaced with the final 2016 version.

    Click here to download the draft of the GRN White Paper.

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  • CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis

    Naert et al. published in Science Reports CRISPr/Cas9-mediated deletion of the retinoblastoma (rb1) and retinoblastoma-like 1 (rbl1) genes. Biallelic inactivation of these genes results in tumor formation. This is the first CRISPR/Cas derived cancer model in the frog and it is the first non-mammalian genetic retinoblastoma cancer model.

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  • A simple and efficient method to visualize and quantify the efficiency of chromosomal mutations from genome editing

    Fu et al. published in Science Reports a simple and efficient method to visualize and quantify the efficiency of genomic mutations induced by genome-editing. Their approach is based on the expression of a two-color fusion protein in a vector that allows the insertion of the edited region in the genome in between the two color moieties.

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  • Cell and Developmental Biology of Xenopus: 2017 Course at Cold Spring Harbor

    March 29 - April 11, 2017

    This course is designed for those new to the Xenopus field, as well as for more advanced students who are interested in emerging technologies.

    Application Deadline: 15 December 2016

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  • 2016 John Gurdon Prize Winner

    This year's recipient is Rachel Stephenson. She is pursuing her graduate studies in laboratory of Ann Miller at the University of Michigan.

    Please click below to learn more about her work and the other award recipients and their research.

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  • Gene Regulatory Systems in Development

    March 27-30, 2017
    Parador de Carmona, Carmona, Spain
    Registration: January 31, 2017
    Abstracts: before December 17, 2016

    The European Marie-Curie consortia DevCom and ZENCODE-ITN are jointly organising this conference. The topics of the conference will be single-cell profiling, chromatin dynamics, regulatory networks and evolutionary plasticity, with a profound role for Xenopus and zebrafish as model organisms.

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  • Updated Xenopus laevis genome annotation

    Gene Model Annotation 1.8.3 of the X. laevis 9.1 Genome Build

    The latest annotation of the X. laevis 9.1 genome is ready!  

    This release only includes updating the gene symbol of existing gene models.  

    The files for this annotation release, GFFs and FASTA, can be downloaded from the Xenbase FTP page, under the X. laevis genome assemblies and gene models category.

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  • 2016 Xenopus White Paper

    Representatives of the research community have released the 2016 Xenopus White Paper summarizing strategic resource development.

    Download: Word Doc, PDF

    PIs: Please reference the White Paper in your NIH grant proposals and contact your program officers.

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  • Developmental Biology: Special Issue

    Volume 408, Issue 2, Pages 179-358
    Modeling Human Development and Disease in Xenopus
    Edited by Carole LaBonne and Aaron Zorn

    Read More...
  • Genome evolution in the allotetraploid frog Xenopus laevis

    Session et al. published in Nature describe the analysis of the subgenomes of the allotetraploid Xenopus laevis. The L subgenome more consistenly resembles the ancestral condition and the S subgenome is more disrupted by deletion and rearrangment.

    Read More...
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