Mitotic chromosome assembly despite nucleosome depletion in Xenopus egg extracts

Shintomi et al. expolited a cell-free system made from Xenopus laevis eggs. Combined with nucleosome-depleted mouse nuclei, they investigate mitotic chromatid structure assembly of DNA in the absence of histones. Published in Science.

In Situ Microprobe Single-Cell Capillary Electrophoresis Mass Spectrometry

Metabolic Reorganization in Single Differentiating Cells in the Live Vertebrate (Xenopus laevis) Embryo.

Onjiko et al. published in Analytical Chemistry their study peering, for the first time, into the formation of metabolic single-cell heterogeneity during early development of a vertebrate embryo.

Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes

Drew et al. integrate the largest-scale mass spectrometry protein interaction datasets from a variety of human and animal cells and tissues. The machine-learning framework generates the most comprehensive and accurate human protein complex map to date. Published in Molecular Systems Biology.

Xenopus Resources and Emerging Technologies Meeting

August 26th – 29th, 2017

at the National Xenopus Resource (NXR) at the Marine Biological Laboratory (MLB) at Wood's Hole, MA.

Xenbase v4.4

Xenbase launched 4 new features (June 2017, Xenbase v 4.4).

1. NEW Interactive RNA-seq temporal expression graphs for trop and laevis.

2. View the latest ‘Xenopus Research Articles’

3. NEW Interactive gene-interaction visualization.

4. Xenopus Article Page, now includes a list of references cited in the paper.

Congratulations to the 2017 SDB Awardees

Society of Developmental Biology awards

Edwin G. Conklin Medal:

Philippe M. Soriano (Icahn School of Medicine at Mount Sinai)

Elizabeth D. Hay New Investigator Award:

Maria Barna (Stanford University)

8th International Course on Developmental Biology

This course is to provides participants with comprehensive coverage of paradigms, problems and technologies of modern Developmental Biology with a particular attention to stem cells.

Workshop: September 18-October 7, 2017/ Seminars: October 9-20, 2017.

Paris, France

Genome evolution in the allotetraploid frog Xenopus laevis

Session et al. published in Nature describe the analysis of the subgenomes of the allotetraploid Xenopus laevis. The L subgenome more consistenly resembles the ancestral condition and the S subgenome is more disrupted by deletion and rearrangment.

Updated Xenopus laevis genome annotation

Gene Model Annotation 1.8.3 of the X. laevis 9.1 Genome Build

The latest annotation of the X. laevis 9.1 genome is ready!  

This release only includes updating the gene symbol of existing gene models.  

The files for this annotation release, GFFs and FASTA, can be downloaded from the Xenbase FTP page, under the X. laevis genome assemblies and gene models category.

2016 Xenopus White Paper

Representatives of the research community have released the 2016 Xenopus White Paper summarizing strategic resource development.

Download: Word Doc, PDF

PIs: Please reference the White Paper in your NIH grant proposals and contact your program officers.

Mitotic chromosome assembly despite nucleosome depletion in Xenopus egg extracts

Shintomi et al. expolited a cell-free system made from Xenopus laevis eggs. Combined with nucleosome-depleted mouse nuclei, they investigate mitotic chromatid structure assembly of DNA in the absence of histones. Published in Science.