Request for Information (RFI): NICHD Strategic Plan Fiscal Years 2020-2024

PLEASE take the time to respond by Feb. 15 and convey your opinions on how your research interests are represented at the NICHD.

Cell and Developmental Biology of Xenopus: 2019 Course at Cold Spring Harbor

April 3-16, 2019

This course is designed for those new to the Xenopus field, as well as for more advanced students who are interested in emerging technologies.

Application Deadline: January 31, 2019

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring

Cagnetta et al. published in Molecular Cell Sema3A triggers the phosphorylation of eIF2α in axons through an initial wave of local protein synthesis. eIF2α phosphorylation upregulates global translation, via differential eIF2B activity, and is required for neural wiring.

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome

Cagnetta et al. published in Neuron a highly sensitive proteomics approach characterizing the nascent proteome of axons on a rapid timescale. Different extrinsic cues trigger distinct signatures of up-/down-regulated nascent protein changes within 5 minutes. 

Mechanical properties during convergent extension

Shawky et al. published in Development demonstrating cortical F-actin density and composition contribute to mechanical cellular properties of convergent extension during embryogenesis.

Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development

Steimle et al. published in PNAS the evolutionary conservation of tbx5-wnt2/2b driving a bidirectional signaling loop between cardiopulmonary mesoderm and the foregut endoderm. This specifies endodermal pulmonary specification and mesodermal cardiac atrial septation.

2nd European Amphibian Conference

Second European Amphibian Club conference to be held 26th-29th June 2019, in Lutherstadt-Wittenberg, Germany.
Abstract deadline: April 15, 2019.

Xenopus animal cap transcriptome

Building a mucociliary epithelium.

Angerilli et al.published in Nucleic Acids Research the dynamic transcriptional landscape in X. tropicalis Animal Cap explants during differentiation into mucociliary epithelium.

Providing an online Web Tool, they detail global changes in mRNA expression, an unanticipated diversity of mRNA splicing isoforms, expression of repetitive DNA elements, and the complexity of circular RNAs.

Gene expression during Xenopus embryogenesis measured at single-cell resolution

Briggs et al. performed single-cell RNA sequencing at 10 embryonic stages 5 to 22 hours post fertilization. Gene activity data read from the mRNA of 137,000 cells show that while the frog embryo appears to be in an undifferentiated state, cells begin to take on their eventual identities. Their findings are published in Science.

Request for Information (RFI): NICHD Strategic Plan Fiscal Years 2020-2024

PLEASE take the time to respond by Feb. 15 and convey your opinions on how your research interests are represented at the NICHD.