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Archived News

  • Xenopus Meetings and Resources
    - 2017-06-15
  • 8th International Course on Developmental Biology
    - 2017-06-15

    This course is to provides participants with comprehensive coverage of paradigms, problems and technologies of modern Developmental Biology with a particular attention to stem cells.

    Workshop: September 18-October 7, 2017/ Seminars: October 9-20, 2017.

    Paris, France

     


    Full Xenbase Post
  • miR-182 Regulates Slit2-Mediated Axon Guidance by Modulating the Local Translation of a Specific mRNA
    - 2017-04-05

    Bellon et al. published in Cell Reports the role of microRNAs in mRNA-specific translation during axonal pathfinding of Xenopus laevis retinal ganglion cells (RGCs). They found that miR-182 targets cofilin-1 mRNA, silencing its translation. Slit2 rapidly relieves this repression without causing miR-182 degradation. Their data support a model where miR-182 reversibly gates the selection of certain mRNAs for fast translation depending on extrinsic cues.

    we investigate the local role of miRNAs in mRNA-specific translation during pathfinding of Xenopus laevis retinal ganglion cell (RGC) axons.

    Full Xenbase Post
  • Leftward Flow Determines Laterality in Conjoined Twins
    - 2017-04-04

    Tisler et al. published in Current Biology their study of an enigmatic left-right defect in conjoined twins. Twins fused at the thorax: left twins are normal, laterality is disturbed in one-half of right twins due to insufficient suppression of the Nodal inhibitor, dand5.


    Full Xenbase Post
  • GO: Gene Ontology terms on Xenbase
    - 2017-02-16

    Expanded representation of Gene Ontology (GO) terms associated with gene product function added to Xenopus gene pages.

    Look for the tab on gene summary pages...


    Full Xenbase Post
  • High variability of expression profiles of homeologous genes for Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus laevis
    - 2017-02-10
  • Genesis Special Issue - Xenopus: Advances and Emerging Technologies
    - 2017-02-07

    Check out the January 2017 issue of Genesis highlighting current advances using Xenopus as a biomedical research model.


    Full Xenbase Post
  • De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome (BAMS) and abrogate nasal development
    - 2017-01-26

    Gordon et al. report in Nature Genetics that missense mutations in the epigenetic regulator SMCHD1 mapping to the extended ATPase domain of the encoded protein cause BAMS in all 14 cases studied.


    Full Xenbase Post
  • Spinal cord regeneration in Xenopus laevis
    - 2017-01-24

    Edwards-Faret et al. describe in Nature Protols their methods for the husbandry of Xenopus laevis tadpoles and froglets and procedures to study spinal cord regeneration.


    Full Xenbase Post
  • IXB: The International Xenopus Board
    - 2017-01-23
  • Call for Papers: Development Special Issue
    - 2017-01-10
  • Congratulations to Professor Sir James Cuthbert Smith, FRS
    - 2017-01-09

    Professor Sir Jim Smith of The Francis Crick Institute was knighted in the Queen's New Year's Honours (2017) for services to medical research and science education.


    Full Xenbase Post
  • Cell and Developmental Biology of Xenopus: 2017 Course at Cold Spring Harbor
    - 2016-12-22

    March 29 - April 11, 2017

    This course is designed for those new to the Xenopus field, as well as for more advanced students who are interested in emerging technologies.

    Application Deadline: January 6, 2017


    Full Xenbase Post
  • European Amphibian Club 2017
    - 2016-12-06
  • Mechanosensing is critical for axon growth in the developing brain
    - 2016-11-16

    Koser et al. identify mechanical signals as important regulators of axon pathfinding. In vitro, substrate stiffness determined growth patterns of Xenopus retinal ganglion cell axons. In vivo atomic force microscopy revealed a noticeable pattern of stiffness gradients in the embryonic brain.

    Published in Nature Neuroscience.


    Full Xenbase Post
  • A simple and efficient method to visualize and quantify the efficiency of chromosomal mutations from genome editing
    - 2016-11-14

    Fu et al. published in Science Reports a simple and efficient method to visualize and quantify the efficiency of genomic mutations induced by genome-editing. Their approach is based on the expression of a two-color fusion protein in a vector that allows the insertion of the edited region in the genome in between the two color moieties.


    Full Xenbase Post
  • Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors
    - 2016-11-14

    Kaminski et al. identified 4 factors that are able to directly reprogram fibroblasts into renal tubule cells.

    Induced renal tubule epithelial cells (iRECs) are similar to their native counterparts with respect to their transcriptional profile and morphological features, and can integrate into kidney organoids and decellularized kidneys.

    Their research is published in Nature Cell Biology.


    Full Xenbase Post
  • Gene Regulatory Networks White Paper 2016
    - 2016-11-07

    A “final” draft of the GRN white paper is in the works, but several people request that the current working white paper draft be made publicly available.

    This would allow everyone to refer to the white paper in grants or manuscripts. The GRN White Paper draft will be hosted on Xenbase.

    This current draft will eventually be replaced with the final 2016 version.

    Click here to download the draft of the GRN White Paper.


    Full Xenbase Post
  • Genome evolution in the allotetraploid frog Xenopus laevis
    - 2016-10-20

    Session et al. published in Nature describe the analysis of the subgenomes of the allotetraploid Xenopus laevis. The L subgenome more consistenly resembles the ancestral condition and the S subgenome is more disrupted by deletion and rearrangment.


    Full Xenbase Post
  • CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis
    - 2016-10-19

    Naert et al. published in Science Reports CRISPr/Cas9-mediated deletion of the retinoblastoma (rb1) and retinoblastoma-like 1 (rbl1) genes. Biallelic inactivation of these genes results in tumor formation. This is the first CRISPR/Cas derived cancer model in the frog and it is the first non-mammalian genetic retinoblastoma cancer model.


    Full Xenbase Post
  • 2016 John Gurdon Prize Winner
    - 2016-10-10

    This year's recipient is Rachel Stephenson. She is pursuing her graduate studies in laboratory of Ann Miller at the University of Michigan.

    Please click below to learn more about her work and the other award recipients and their research.


    Full Xenbase Post
  • Metrics to Assess Value of Biomedical Digital Repositories
    - 2016-10-03
  • Gene Regulatory Systems in Development
    - 2016-09-29

    March 27-30, 2017
    Parador de Carmona, Carmona, Spain
    Registration: January 31, 2017
    Abstracts: extended to January 31, 2017

    The European Marie-Curie consortia DevCom and ZENCODE-ITN are jointly organising this conference. The topics of the conference will be single-cell profiling, chromatin dynamics, regulatory networks and evolutionary plasticity, with a profound role for Xenopus and zebrafish as model organisms.


    Full Xenbase Post
  • DeLill Nasser Award for Professional Development in Genetics
    - 2016-09-29
  • Identification of Genetic and Genomic Variants by Next-Gen Sequencing in Non-human Animal Models (U01)
    - 2016-09-29
  • Xenopus Workshops and Meetings at the NXR
    - 2016-09-21
  • 2016 Xenopus Research Resource Survey
    - 2016-08-28

    We seek your feedback regarding the many Xenopus research resources.

    Please follow this link or click below to take the survey on Xenbase!


    Full Xenbase Post
  • 8th Aquatic Animal Models of Human Disease Conference
    - 2016-08-08
  • Single-cell mass spectrometry comparing metabolites in left and right cells in the 8-cell Xenopus laevis embryo
    - 2016-07-22

    Onjiko et al. used single-cell mass spectrometry to compare left and right cells in the 8-cell Xenopus laevis embryo.

    Of hundreds of different metabolites detected, 10 were found to be asymmetrically accumulated between the left and right cells.

    Featured article in the journal, Analyst.


    Full Xenbase Post
  • Gene Regulatory Networks for Development Course at MBL
    - 2016-07-21

    Special Topics Course: Gene Regulatory Networks for Development

    October, 9-22, 2016

    Marine Biological Laboratory, Woods Hole, MA

    Deadline to apply: July 29, 2016


    Full Xenbase Post
  • 7th international Curie/UPMC Developmental Biology Course
    - 2016-07-20
  • GSA Seeks Support Regarding MOD Funding
    - 2016-06-30

    The Genetics Society of America (GSA) is seeking support for revision of plans to consolidate and reduce the funding of MODs funded by the National Human Genome Research Institute (NHGRI/NIH).


    Full Xenbase Post
  • Updated Xenopus laevis genome annotation
    - 2016-06-03

    Gene Model Annotation 1.8.3 of the X. laevis 9.1 Genome Build

    The latest annotation of the X. laevis 9.1 genome is ready!  

    This release only includes updating the gene symbol of existing gene models.  

    The files for this annotation release, GFFs and FASTA, can be downloaded from the Xenbase FTP page, under the X. laevis genome assemblies and gene models category.


    Full Xenbase Post
  • Xenbase-NXR RRID Initiative
    - 2016-05-26
  • NIGMS Seeks Input on Resource Needs and Team Science
    - 2016-05-19

    The National Institute of General Medical Sciences (NIGMS) released requests for information (RFI) in April asking for input on resource needs and “team science.”

    Please advocate for Xenopus biomedical research!

    Comments due by June 3, 2016.


    Full Xenbase Post
  • 2016 National Academy of Sciences
    - 2016-05-16

    Xenbase, and on behalf of the world wide Xenopus research community, congratulates the newly appointed members to the National Academy of Sciences who both currently and in earlier times in their careers, use Xenopus in their research.


    Full Xenbase Post
  • 2016 Xenopus White Paper
    - 2016-05-09

    Representatives of the research community have released the 2016 Xenopus White Paper summarizing strategic resource development.

    Download: Word Doc, PDF

    PIs: Please reference the White Paper in your NIH grant proposals and contact your program officers.


    Full Xenbase Post
  • American Academy of Arts and Sciences 2016 Newly Elected Members
    - 2016-05-02

    Congratulations to Christof Niehrs and Nancy Ip for being elected to the American Academy of Arts and Sciences.


    Full Xenbase Post
  • Noggin4 is a long-range inhibitor of Wnt8 (not BMP) signalling that regulates head development in Xenopus laevis
    - 2016-04-13

    Eroshkin et al.

    Scientific Reports 6, Article number: 23049 (2016)


    Full Xenbase Post
  • Xenbase Release 3.11.0
    - 2016-04-12
    • Transgene links added to gene pages
    • RRID field added for antibodies
    • Proper name display for lines, transgenes, and strains
    • Reformatted the "Cite Xenbase" page; added Xenbase publications

    Full Xenbase Post
  • 2016 Weinstein Cardiovascular Development and Regeneration Conference
    - 2016-03-16
  • Searchable Databases of Xenopus RNA-Seq Expression Profiles
    - 2016-02-22

    Update: Owens et al. published in Cell Reports high-resolution, absolute number mRNA transcript data during X. tropicalis development from fertilization to tadpole stages, a developmental period approximating the first 8 weeks of human gestation.


    Full Xenbase Post
  • 2016 Xenopus Bioinformatics and Genome Editing Workshops
    - 2016-02-12

    Registration now open.

    Bioinformatics workshop: May 1-7, 2016

    Genome Editing workshop: May 6-14, 2016

    at the NXR at the MBL in Woods Hole, Massachusetts.

    Discounted costs if you attend both workshops!


    Full Xenbase Post
  • Epigenome reference map track hub
    - 2016-02-10

    Update:

    Track hubs now include trop v9.1 assebly. A collection of over 70 epigenome reference maps of Xenopus tropicalis early development has been released with the publication of “Embryonic transcription is controlled by maternally defined chromatin state” in Nature Communications.

    For instructions click here.


    Full Xenbase Post
  • RNA whole-mount in situ hybridization proximity ligation assay (rISH-PLA)
    - 2016-02-10
  • Xenopus phylogeny revised: six new species
    - 2016-01-26

    Six new polyploid speciies added, plus one species is reinstated.

    The new classifications are made by using multiple sources of information, including DNA, recordings of vocalizations, CT scanning of internal anatomy, and chromosome analysis. 

     

    Evans et al., PLoS One. 2015 Dec 16;10(12).

     


    Full Xenbase Post
  • Cell and Developmental Biology of Xenopus: 2016 Course at Cold Spring Harbor
    - 2016-01-04

    Gene Discovery & Disease

    April 5-18, 2016

    Instructors:

    Mustafa Khokha, Yale University

    Karen Liu, King's College London, UK


    Full Xenbase Post
  • Xenbase Release 3.8
    - 2015-12-07
    • Added IMPC mouse phenotype gene page links
    • Added PANTHER GO search links on gene pages
    • Added XenMine links on gene pages (Data Mining section)
    • Reformatted stock centre search and display
    • Bug fixes and enhancements

    Full Xenbase Post
  • Whitman Center Fellowship Program at the MBL
    - 2015-12-01
  • On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development
    - 2015-11-10

    Peshkin et al. published in Developmental Cell

    • A genome-scale resource of mRNA and protein expression for vertebrate embryogenesis
    • Temporal patterns of change in mRNA and protein abundance are poorly correlated
    • A simple kinetic model explains protein expression as a function of mRNA levels
    • Embryogenesis is driven by maternal protein dowry and tissue-specific transcription

    Full Xenbase Post
  • 16th International Xenopus Conference
    - 2015-10-27

    Registration now open.

    The biennial gathering of Xenopus biomedical researchers:

    Aug. 28th - Sept. 1st, 2016

    Orthodox Academy of Crete, Chania

    Click here to go to the meeting website.


    Full Xenbase Post
  • Advanced Imaging Workshop at the MBL
    - 2015-09-29
  • Xenopus laevis genome v9.1 released
    - 2015-09-17

    The Xenopus laevis genome v9.1 is available at chromosome scale.

    It can be accessed via BLAST or by selecting the 9.1 version within GBrowse.

    ...or click here to go directly.

    X. laevis genome v8.0 is now retired due to missing regions.


    Full Xenbase Post
  • NSF Funding Opportunities
    - 2015-09-17

    Small Buisiness Innovation Research (SBIR) and Small Business Technology Transfer (STTR) projects on Advanced Technologies for Functional Genomics in Organismal Systems


    Full Xenbase Post
  • Genesis: Special Issue
    - 2015-09-16
  • Developmental Biology: Genomics Special Issue
    - 2015-08-31
  • NIH launches new initiative to study the basis of human birth defects
    - 2015-08-04

    There are some important funding opportunities at the NIH in which the utility of Xenopus for research in human congenital disorders is ideal.

    RFA-HD-16-009 now released.


    Full Xenbase Post
  • 6th Course on Developmental Biology
    - 2015-06-29
  • Congratulations to the 2015 Society of Developmental Biology award winners
    - 2015-06-24
  • Xenopus models for Human eye diseases
    - 2015-06-22

    Recent studies in Xenopus on eye development genes phenocopy human clinical pathologies.


    Full Xenbase Post
  • Xenopus laevis genome v8.0 released
    - 2015-06-18

    The Xenopus laevis genome v8.0 is available at chromosome scale.

    It can be accessed via BLAST or by selecting the 8.0 version within GBrowse.


    Full Xenbase Post
  • The BSDB introduces the Cheryll Tickle Award
    - 2015-06-16
  • Xenbase Release 3.5
    - 2015-06-03
    • Updated FTP landing page for data downloads
    • Release of new feature ORFeome v1.0
    • Migration of NCBI E-utilities from SOAP to REST
    • laevis-only genes now display on gene pages
    • Latest XAO update added

    Full Xenbase Post
  • Xenbase Spring Newsletter 2015
    - 2015-05-15
    • Xenopus ORFeome v1.0
    • Outbred X. laevis Genome
    • Updated Genome Browser Tracks
    • Data Downloads
    • X. laevis Chromosome Nomenclature
    • Newly Nominated National Academy Members

    Full Xenbase Post
  • 2015 Xenopus PI Meeting
    - 2015-05-11
  • Portuguese Society for Developmental Biology, 3rd Meeting
    - 2015-04-08
  • BSCB/BSDB Joint Spring Meeting 2015
    - 2015-03-24
  • 2015 Gordon Research Conference on Neural Crest & Cranial Placodes
    - 2015-03-24
  • Size matters: the bigger the nucleus, the sooner transcription begins
    - 2015-03-04

    Jevtic and Levy report in Current Biology nuclear size scaling in Xenopus early development contributes to midblastula transition timing.


    Full Xenbase Post
  • Xenopus oocytes used to characterize rare disease caused by potassium channel mutations
    - 2015-03-04

    Simons et al. report in Nature Genetics analyzing the activity of mutations in human KCNH1 voltage-gated potassium channels related to Temple-Baraitser syndrome in Xenopus oocytes.


    Full Xenbase Post
  • 2015 Gordon Research Conference on Developmental Biology
    - 2015-03-03
  • UK Xenopus Meeting
    - 2015-02-06
  • Highly efficient gene knockout by injection of TALEN mRNAs into oocytes and host transfer in X. laevis
    - 2015-01-22

    Nakajima & Yaoita describe in the journal, Biology Open, a combination of oocyte injection of TALEN mRNA injection with oocyte host transfer enhances effectiveness of gene modification.


    Full Xenbase Post
  • Protege Short Course
    - 2015-01-15
  • Symposium: Systems Biology of Development and Differentiation
    - 2015-01-05
  • Recent genome-wide analyses in Xenopus
    - 2014-12-10

    We highlight a collection of recent articles detailing genome-wide analysis in Xenopus using high-throughput ChIP-seq and RNA-seq methods.

    Check them out!


    Full Xenbase Post
  • Cell and Developmental Biology of Xenopus: 2015 Course at Cold Spring Harbor
    - 2014-12-02

    Gene Discovery and Disease

    April 9-21, 2015

    Scholarships available! Application deadline February 23, 2015

    Instructors:

    Mustafa Khokha, Yale University

    Karen Liu, King's College London, UK


    Full Xenbase Post
  • 48th Annual Meeting of the Japanese Society of Developmental Biologists
    - 2014-12-02
  • A Tribute to Sir John Gurdon
    - 2014-11-25
  • Cytokinesis signaling visualized in vitro, using Xenopus cell-free system
    - 2014-11-07

    Nguyen et al. reconstituted cytokinesis protein organization outside living cells, using a system derived from Xenopus egg extracts. This article is available from Science.


    Full Xenbase Post
  • Xenbase Release v3.3
    - 2014-10-30

    · New morpholino feature added
    · New genome builds and gene models
    · Transgenic nomenclature guidelines
    · New genome editing links added
    · GEISHA (chicken) orthology imported into database and added to gene pages
    · 10,000+ PubMed Central (PMC) article images added to Xenbase
    · OMIM disorders associated with Xenopus genes added to gene pages

    Check out the Xenopus antibody database and improved genome browser.

    Please send us comments and feedback.


    Full Xenbase Post
  • DevCom Workshop
    - 2014-10-14
  • National Xenopus Resource at the MBL
    - 2014-09-25
  • Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity
    - 2014-09-18

    Sojka et al. published in the journal Development their findings that the cardiac transcription factor CASTOR (CASZ1) directly interacts with contenital heart disease 5 protein (CHD5).


    Full Xenbase Post
  • 15th International Xenopus Meeting
    - 2014-09-04

    Many thanks to Carole Labonne and John Wallingford and the GSA for organizing a wonderful meeting!

    The biennial gathering of Xenopus biomedical researchers:

    August 24th - 28th, 2014 in Asilomar, CA

    Click here to go to the meeting website.

     


    Full Xenbase Post
  • Xenopus genome editing workshop
    - 2014-09-04

    Nov. 9-15, 2014

    at the NXR in Woods Hole, Massachusetts.

    Click here to view the syllabus.


    Full Xenbase Post
  • A celebration of the life and genius of Yoshiki Sasai (1962-2014): An obituary
    - 2014-08-25

    Enrique Amaya details the pioneering work of Dr. Yoshiki Sasai.


    Full Xenbase Post
  • 52nd Annual Midwest Society for Developmental Biology Meeting
    - 2014-08-22
  • Gene Regulatory Networks for Development
    - 2014-08-15
  • Firing and wiring: Hebbian axonal remodelling in Xenopus
    - 2014-08-12

    Munz et al. report in the journal Science their examination of axon remodelling of ipsilaterally projected retinal ganglion cells (RGCs) in response to synchronous or asynchronous firing.


    Full Xenbase Post
  • Smells Like Development
    - 2014-08-11
  • The 7th Aquatic Animal Models of Human Disease Conference
    - 2014-08-11

    December 13-18, 2014, Austin, Texas

    $500 Travel Award sponosored by Genesis, the Journal of Genetics and Development for junior Xenopus investigators

    Keynote Speaker: Monte Westerfield


    Full Xenbase Post
  • Sp8 regulates inner ear development
    - 2014-05-12

    Chung et al. published in The Proceedings of the National Academy of Sciences that the eclipse mutant of Xenopus tropicalis has alterations in the sp8 gene locus. These tadpoles had decreased startle reflexes and altered swimming balance resulting from faulty embryonic inner ear development.

     


    Full Xenbase Post
  • A new Xenopus model for Urofacial Syndrome
    - 2014-05-08

    Roberts et al. identified and knocked down the Xenopus orthologue of human HPSE2: establishing for the first time an in vivo vertebrate model for urofacial syndrome (UFS). This is the first study to shed light on the mechanisms underpinning the clinical features of UFS.


    Full Xenbase Post
  • Timothy Mitchison and Andrew Murray elected to membership of the National Academy of Sciences
    - 2014-05-02

    Dr. Mitchison and Dr. Murray's seminal research using Xenopus egg cell extracts greatly contributes to our understanding of the cell cycle progression and cell division.

     

     


    Full Xenbase Post
  • Developmental Biology: Xenopus Issue
    - 2014-05-01

    Submissions to a special issue of the journal Developmental Biology entitled: Modeling Human Development and Disease in Xenopus will open on August 1, 2014. Manuscripts can be submitted until November 1 2014, although earlier is better. Peer review must be completed and manuscript disposition determined no later than March 15th 2015, for publication in late spring.


    Full Xenbase Post
  • Richard Harland elected to membership of the National Academy of Sciences; awarded the SDB 2014 Conklin Medal
    - 2014-04-30

    Dr. Harland found that BMP antagonists are fundamental for the patterning of germ layers. His research expands our knowledge of neural induction/patterning, FGF signaling, planar cell polarity, and developmental control of RNA splicing.


    Full Xenbase Post
  • Quantitative proteomics of Xenopus laevis embryos
    - 2014-04-24

    Expression kinetics of nearly 4000 proteins during early development.

     

    Sun et al. report the largest developmental proteomic dataset for any animal.

     

     


    Full Xenbase Post
  • PCP and Septins Compartmentalize Cortical Actomyosin to Direct Collective Cell Movement
    - 2014-04-23

    Shindo & Wallingford, published in the journal, Science that planar cell polarity (PCP) proteins control convergent extension by exploiting an evolutionarily ancient function of the septin cytoskeleton.

    (shown: phospho-myosin light chain in embryonic notochord cell membranes)


    Full Xenbase Post
  • SDB 73rd Annual Meeting
    - 2014-04-15

    Dr. Richard Harland will be honored with the The Society for Developmental Biology’s E.G. Conklin Medal.

     

    Dr. Janet Heasman and Dr. Christopher Wylie will recognized for their lifetime achievements in developmental biology.

     

    For meeting information please visit: sdbonline.org/2014mtg

     


    Full Xenbase Post
  • CRISPr/Cas9-mediated targeted mutagenesis in Xenopus
    - 2014-03-18

    In back-to-back articles published in genesis, Blitz et al. and Nakayama et al. each report CRISPr/Cas targeted transgenesis works well in Xenopus tropicalis.

    For additional information on genome editing techonologies, click here.

    (shown: targeted silencing of six6 and tyrosinase genes)


    Full Xenbase Post
  • 2014 Xenopus White Paper
    - 2014-03-14

    Representatives of the research community have released the 2014 Xenopus White Paper summarizing strategic resource development.
     

    Download 2014 Xenopus White Paper

     

     


    Full Xenbase Post
  • 2014 Xenbase Survey
    - 2014-02-27

    Please take our survey!

     

    Your feedback is essential for guiding us to better serve your research needs.

    Your opinion matters to us!

     

    Click here to launch the survey

     

    Thank you for the responses so far!

    Please keep them coming.

     

    We will be closing the survey on Friday March 11, 2014.

     

    Full Xenbase Post
  • Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition by locomotion
    - 2014-02-04

    Moore et al. report the requirement for par3 to regulate cellular microtuble breakdown as neural crest cells migrate.

     


    Full Xenbase Post
  • Cell & Developmental Biology of Xenopus at CSHL
    - 2014-02-03

    Course at Cold Spring Harbor Laboratories - April 4-15, 2014

    Registration now open!

     


    Full Xenbase Post
  • 3rd Annual Xenopus Bioinformatics Workshop
    - 2014-01-31

    Registration now open. The workshop will be held May 11-18 at the MBL in Woods Hole, MA.

     


    Full Xenbase Post
  • Christopher Wylie and Janet Heasman Honored with SDB Lifetime Achievement Award
    - 2014-01-29

    Wylie and Heasman are being honored for their outstanding and sustained research and mentoring contributions to the field of developmental biology.

     


    Full Xenbase Post
  • 2014 Xenopus White Paper (edit requests)
    - 2014-01-28

    Representatives of the research community have drafted a 2014 Xenopus White Paper summarizing strategic resource development.
     

    Please review, make comments on, and sign the Xenopus White Paper.


     


    Full Xenbase Post
  • UK Xenopus Meeting
    - 2014-01-03

    February 28, 2014

    King's College, London

    Deadline for registration (Free) is 15 January 2014.

    UK researchers gather for their annual meeting in London.

     


    Full Xenbase Post
  • Eddy De Robertis and Nick Spitzer elected members of the National Academy of Science
    - 2013-12-17

    Dr. De Robertis and Dr. Spitzer recognized for their work in dorsal-ventral embryonic patterning and mechanisms of neural differentiation

     


    Full Xenbase Post
  • New Xenopus Genome Assemblies
    - 2013-12-11

    The Xenopus Genome Consortium has released the newest laevis v7.1 and tropicalis v8.0 assemblies.

     


    Full Xenbase Post
  • Insights into autism and epilepsy using Xenopus
    - 2013-11-19

    The Xenopus tadpole model offers many advantages for studying the molecular, cellular and network mechanisms underlying neurodevelopmental disorders.

     

    Modified image from Chris Ciarlegilio detecting GABA (green) in the CNS from a stage 49 tadpole.

     


    Full Xenbase Post
  • Xenopus as a disease model for heterotaxy in humans
    - 2013-11-11

    Heterotaxy gene GALNT11 glygosylates Notch to orchestrate cilia type and laterality. Published online November 13, 2013 in Nature.

     


    Full Xenbase Post
  • Xenopus advances regeneration studies
    - 2013-11-01

    Amaya and Slack labs enhance regenerative studies using Xenopus

     


    Full Xenbase Post
  • In vivo Microtomography of Xenopus Gastrulation
    - 2013-10-17

    Moosmann et al. in a multi-center collaboration, captured amazing 4D images of coordinated cell movements in gastrulating embryos. Published in the May 15th issue of Nature.

     


    Full Xenbase Post
  • Marianne Bronner Receives 2013 Conklin Medal
    - 2013-10-16

    Her fundamental research using animal models including Xenopus contributes tremendously to our understanding of neural crest development and biology.


    Full Xenbase Post
  • Jim Smith Awarded 2013 Waddington Medal
    - 2013-10-16

    His current research investigates how cells of the very early vertebrate embryo form specialised tissues such as muscle, skin, blood and bone.

     


    Full Xenbase Post
  • 2013 Xenopus PI Meeting Summary
    - 2013-09-06

    Meeting held August 23-25, 2013 at the MBL in Woods Hole, MA USA

     

    Researchers from around the world came together to discuss the Xenopus White Paper and community resources.

     


    Full Xenbase Post
  • Developmental Neurobiology: Xenopus Issue
    - 2013-09-05

    April 2012

    Volume 72, Issue 4

    Pages 463–675

    Issue edited by Hollis T. Cline and Darcy B. Kelley

     


    Full Xenbase Post
  • Genesis: Xenopus Special Issue
    - 2013-09-05

    Genesis: March 2012

    Vol. 50, Issue 3

    pages 133-332

    Issue edited by Lyle Zimmerman and Sally A. Moody

     


    Full Xenbase Post
  • John Gurdon Wins 2012 Nobel Prize
    - 2013-08-10

    John B Gurdon (Cambridge, UK) and Shinya Yamanaka (Tokyo, Japan) share the 2012 Nobel prize for medicine or physiology.


    Full Xenbase Post
  • Welcome to the new Xenbase
    - 2013-08-01

    In addition to our new look, check out the new Xenopus antibody database and improved genome browser.

     

    Please send us comments and feedback.

     

     


    Full Xenbase Post

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version: [4.4.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556