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Cell Rep 2019 Jun 04;2710:2962-2977.e5. doi: 10.1016/j.celrep.2019.05.013.
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Endodermal Maternal Transcription Factors Establish Super-Enhancers during Zygotic Genome Activation.

Paraiso KD , Blitz IL , Coley M , Cheung J , Sudou N , Taira M , Cho KWY .

Elucidation of the sequence of events underlying the dynamic interaction between transcription factors and chromatin states is essential. Maternal transcription factors function at the top of the regulatory hierarchy to specify the primary germ layers at the onset of zygotic genome activation (ZGA). We focus on the formation of endoderm progenitor cells and examine the interactions between maternal transcription factors and chromatin state changes underlying the cell specification process. Endoderm-specific factors Otx1 and Vegt together with Foxh1 orchestrate endoderm formation by coordinated binding to select regulatory regions. These interactions occur before the deposition of enhancer histone marks around the regulatory regions, and these TFs recruit RNA polymerase II, regulate enhancer activity, and establish super-enhancers associated with important endodermal genes. Therefore, maternal transcription factors Otx1, Vegt, and Foxh1 combinatorially regulate the activity of super-enhancers, which in turn activate key lineage-specifying genes during ZGA.

PubMed ID: 31167141
PMC ID: PMC6610736
Article link: Cell Rep
Grant support: [+]

Species referenced: Xenopus tropicalis
Genes referenced: admp atf6 c3h5orf15 ccdc17 ctnnb1 dicer1 eef1a1 ep300 ezh2 fgf20 foxa2 foxa4 foxh1 foxh1.2 foxi2 frzb gata6 gdf1 gdf3 grhl1 gsc hhex hhipl1l hkdc1 homeobox100496651-provisional id3 jarid2 kif28 mix1 mixer nodal nodal6 odc1 opn7a otx1 otx2 pbx1 pnhd pou5f3.1 smarcc2 snai1 sox17b.1 sox7 sprtnl2 (provisional) ubl5 vegt XB22065605 [provisional:sprtn] XB5964940 [provisional] znf783 (provisional) zscan30
Antibodies: VegT Ab2
Morpholinos: foxh1 MO2 otx1 MO2 vegt MO10

GEO Series: GSE118024: Xenbase,  NCBI

Article Images: [+] show captions
References [+] :
, Expansion of the Gene Ontology knowledgebase and resources. 2017, Pubmed