Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Mol Cell Biol
2013 Jan 01;331:48-58. doi: 10.1128/MCB.00904-12.
Show Gene links
Show Anatomy links
An unusual two-step control of CPEB destruction by Pin1.
Nechama M
,
Lin CL
,
Richter JD
.
???displayArticle.abstract???
Cytoplasmic polyadenylation is a conserved mechanism that controls mRNA translation and stability. A key protein that promotes polyadenylation-induced translation of mRNAs in maturing Xenopus oocytes is the cytoplasmic polyadenylation element binding protein (CPEB). During this meiotic transition, CPEB is subjected to phosphorylation-dependent ubiquitination and partial destruction, which is necessary for successive waves of polyadenylation of distinct mRNAs. Here we identify the peptidyl-prolyl cis-trans isomerase Pin1 as an important factor mediating CPEB destruction. Pin1 interacts with CPEB in an unusual manner in which it occurs prior to CPEB phosphorylation and prior to Pin1 activation by serine 71 dephosphorylation. Upon induction of maturation, CPEB becomes phosphorylated, which occurs simultaneously with Pin1 dephosphorylation. At this time, the CPEB-Pin1 interaction requires cdk1-catalyzed CPEB phosphorylation on S/T-P motifs. Subsequent CPEB ubiquitination and destruction are mediated by a conformational change induced by Pin1 isomerization of CPEB. Similar to M phase progression in maturing Xenopus oocytes, the destruction of CPEB during the mammalian cell cycle requires Pin1 as well. These data identify Pin1 as a new and essential factor regulating CPEB degradation.
Abrahamsen,
Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes.
2012, Pubmed
Abrahamsen,
Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes.
2012,
Pubmed
Ballantyne,
A dependent pathway of cytoplasmic polyadenylation reactions linked to cell cycle control by c-mos and CDK1 activation.
1997,
Pubmed
,
Xenbase
Barnard,
Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.
2004,
Pubmed
,
Xenbase
Berger,
Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage.
2005,
Pubmed
Burns,
CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation.
2008,
Pubmed
Burns,
CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation.
2011,
Pubmed
Cao,
CDK1 and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progression.
2006,
Pubmed
,
Xenbase
Cao,
Dissolution of the maskin-eIF4E complex by cytoplasmic polyadenylation and poly(A)-binding protein controls cyclin B1 mRNA translation and oocyte maturation.
2002,
Pubmed
,
Xenbase
Crenshaw,
The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1.
1998,
Pubmed
,
Xenbase
Eckerdt,
Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells.
2005,
Pubmed
Fujimoto,
Proline cis/trans-isomerase Pin1 regulates peroxisome proliferator-activated receptor gamma activity through the direct binding to the activation function-1 domain.
2010,
Pubmed
Groisman,
Control of cellular senescence by CPEB.
2006,
Pubmed
Groisman,
Translational control of the embryonic cell cycle.
2002,
Pubmed
,
Xenbase
Groppo,
CPEB control of NF-kappaB nuclear localization and interleukin-6 production mediates cellular senescence.
2011,
Pubmed
Gutierrez,
Ubiquitin and SUMO systems in the regulation of mitotic checkpoints.
2006,
Pubmed
Hake,
CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation.
1994,
Pubmed
,
Xenbase
Hodgman,
CPEB phosphorylation and cytoplasmic polyadenylation are catalyzed by the kinase IAK1/Eg2 in maturing mouse oocytes.
2001,
Pubmed
,
Xenbase
Hunter,
The age of crosstalk: phosphorylation, ubiquitination, and beyond.
2007,
Pubmed
Kim,
Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation.
2006,
Pubmed
,
Xenbase
Lee,
Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function.
2011,
Pubmed
Lee,
Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease.
2011,
Pubmed
Lin,
Transient CPEB dimerization and translational control.
2012,
Pubmed
Lin,
The nuclear experience of CPEB: implications for RNA processing and translational control.
2010,
Pubmed
,
Xenbase
Liou,
Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins.
2011,
Pubmed
Lu,
Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function.
2002,
Pubmed
Mendez,
Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA.
2000,
Pubmed
,
Xenbase
Mendez,
Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex.
2000,
Pubmed
,
Xenbase
Mendez,
Differential mRNA translation and meiotic progression require Cdc2-mediated CPEB destruction.
2002,
Pubmed
,
Xenbase
Nakamura,
Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease.
2012,
Pubmed
Nechama,
The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism.
2009,
Pubmed
Nechama,
Correction for Nechama et al., "An Unusual Two-Step Control of CPEB Destruction by Pin1".
2017,
Pubmed
Orlicky,
Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase.
2003,
Pubmed
Piqué,
A combinatorial code for CPE-mediated translational control.
2008,
Pubmed
,
Xenbase
Reverte,
CPEB degradation during Xenopus oocyte maturation requires a PEST domain and the 26S proteasome.
2001,
Pubmed
,
Xenbase
Richter,
CPEB: a life in translation.
2007,
Pubmed
,
Xenbase
Sarkissian,
Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3.
2004,
Pubmed
,
Xenbase
Setoyama,
Mechanism of degradation of CPEB during Xenopus oocyte maturation.
2007,
Pubmed
,
Xenbase
Silverman,
SCF ubiquitin ligases in the maintenance of genome stability.
2012,
Pubmed
Stebbins-Boaz,
Maskin is a CPEB-associated factor that transiently interacts with elF-4E.
1999,
Pubmed
,
Xenbase
Tay,
The control of cyclin B1 mRNA translation during mouse oocyte maturation.
2000,
Pubmed
Weissman,
The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation.
2011,
Pubmed
Werner-Allen,
cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72.
2011,
Pubmed
Whitfield,
Identification of genes periodically expressed in the human cell cycle and their expression in tumors.
2002,
Pubmed
Zhou,
Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins.
2000,
Pubmed
de Moor,
The Mos pathway regulates cytoplasmic polyadenylation in Xenopus oocytes.
1997,
Pubmed
,
Xenbase
