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Nat Commun May 13, 2014; 5 3734.
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Role of Rab11 in planar cell polarity and apical constriction during vertebrate neural tube closure.

Ossipova O , Kim K , Lake BB , Itoh K , Ioannou A , Sokol SY .

Epithelial folding is a critical process underlying many morphogenetic events including vertebrate neural tube closure, however, its spatial regulation is largely unknown. Here we show that during neural tube formation Rab11-positive recycling endosomes acquire bilaterally symmetric distribution in the Xenopus neural plate, being enriched at medial apical cell junctions. This mediolateral polarization was under the control of planar cell polarity (PCP) signalling, was necessary for neural plate folding and was accompanied by the polarization of the exocyst component Sec15. Our further experiments demonstrate that similar PCP-dependent polarization of Rab11 is essential for ectopic apical constriction driven by the actin-binding protein Shroom and during embryonic wound repair. We propose that anisotropic membrane trafficking has key roles in diverse morphogenetic behaviours of individual cells and propagates in a tissue by a common mechanism that involves PCP.

PubMed ID: 24818582
PMC ID: PMC4097039
Article link: Nat Commun
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: abl1 actl6a ankrd6 cfp ctnnb1 dvl1 myc prkci rab11a shroom3 sox3 tjp1 vangl2
Morpholinos: ankrd6 MO1 rab11a MO1 vangl2 MO2


Article Images: [+] show captions
References [+] :
Bayly, Pointing in the right direction: new developments in the field of planar cell polarity. 2011, Pubmed