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Philos Trans R Soc Lond B Biol Sci October 12, 2020; 375 (1809): 20190559.
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Dynamic expression of MMP28 during cranial morphogenesis.

Matrix metalloproteinases (MMPs) are a large family of proteases comprising 24 members in vertebrates. They are well known for their extracellular matrix remodelling activity. MMP28 is the latest member of the family to be discovered. It is a secreted MMP involved in wound healing, immune system maturation, cell survival and migration. MMP28 is also expressed during embryogenesis in human and mouse. Here, we describe the detailed expression profile of MMP28 in Xenopus laevis embryos. We show that MMP28 is expressed maternally and accumulates at neurula and tail bud stages specifically in the cranial placode territories adjacent to migrating neural crest cells. As a secreted MMP, MMP28 may be required in neural crest-placode interactions. This article is part of a discussion meeting issue ''Contemporary morphogenesis''.

PubMed ID: 32829678
PMC ID: PMC7482215
Article link: Philos Trans R Soc Lond B Biol Sci
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: dmrta1 foxi4.1 mmp28 six1 snai2 sox10 sox2 twist1

References [+] :
Aoki, Sox10 regulates the development of neural crest-derived melanocytes in Xenopus. 2003, Pubmed, Xenbase