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XB-ART-58820
Dev Biol March 1, 2022; 483 157-168.
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Hif1α and Wnt are required for posterior gene expression during Xenopus tropicalis tail regeneration.

Patel JH , Schattinger PA , Takayoshi EE , Wills AE .


Abstract
Regeneration of complex tissues is initiated by an injury-induced stress response, eventually leading to activation of developmental signaling pathways such as Wnt signaling. How early injury cues are interpreted and coupled to activation of these developmental signals and their targets is not well understood. Here, we show that Hif1α, a stress induced transcription factor, is required for tail regeneration in Xenopus tropicalis. We find that Hif1α is required for regeneration of differentiated axial tissues, including axons and muscle. Using RNA-sequencing, we find that Hif1α and Wnt converge on a broad set of genes required for posterior specification and differentiation, including the posterior hox genes. We further show that Hif1α is required for transcription via a Wnt-responsive element, a function that is conserved in both regeneration and early neural patterning. Our findings indicate that Hif1α has regulatory roles in Wnt target gene expression across multiple tissue contexts.

PubMed ID: 35065905
Article link: Dev Biol
Grant support: [+]

Species referenced: Xenopus tropicalis
Genes referenced: axin2 cdx4 en2 fgf20 hoxa10 hoxa11 hoxa13 hoxa3 hoxa4 hoxa5 hoxa7 hoxa9 hoxb4 hoxb7 hoxb8 hoxc10 hoxc8 hoxc9 hoxd10 hoxd11 hoxd13 hoxd9 otx2 pafah1b1 prickle1 sall1 sall4 snai2 sox2 wnt5a wnt5b
GO keywords: tissue development [+]
Morpholinos: hif1a MO3

GEO Series: GSE174798: NCBI

Article Images: [+] show captions
References [+] :
Barriga, The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition. 2013, Pubmed, Xenbase