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Proc Natl Acad Sci U S A October 28, 1997; 94 (22): 11980-5.
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Xenopus Zic3, a primary regulator both in neural and neural crest development.

Nakata K , Nagai T , Aruga J , Mikoshiba K .

Xenopus Zic3 is a Xenopus homologue of mouse Zic and Drosophila pair-rule gene, odd-paired. We show here that Zic3 has significant roles both in neural and neural crest development in Xenopus embryo. Expression of Zic3 is first detected in prospective neural plate region at gastrulation. Onset of the expression was earlier than most proneural genes and followed chordin expression. The expression was induced by blockade of BMP4 signal. Overexpression of Zic3 resulted in hyperplastic neural and neural crest derived tissue. In animal cap explant, the overexpression of Zic3 induced expression of all the proneural genes and neural crest marker genes. These findings suggest that Zic3 can determine the ectodermal cell fate and promote the earliest step of neural and neural crest development.

PubMed ID: 9342348
PMC ID: PMC23676
Article link: Proc Natl Acad Sci U S A

Species referenced: Xenopus
Genes referenced: actl6a ascl2 bmp4 chrd.1 en2 h4c4 hoxa9 hoxb9 hoxc9 krt12.4 ncam1 neurod1 neurod4 neurog1 pou3f4 snai2 tbxt twist1 zic3

Article Images: [+] show captions
References [+] :
Aruga, A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. 1994, Pubmed