XB-ART-15895
Proc Natl Acad Sci U S A
October 28, 1997;
94
(22):
11980-5.
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Xenopus Zic3, a primary regulator both in neural and neural crest development.
Nakata K
,
Nagai T
,
Aruga J
,
Mikoshiba K
.
Abstract
Xenopus Zic3 is a Xenopus homologue of mouse Zic and Drosophila pair-rule gene, odd-paired. We show here that Zic3 has significant roles both in neural and neural crest development in Xenopus embryo. Expression of Zic3 is first detected in prospective neural plate region at gastrulation. Onset of the expression was earlier than most proneural genes and followed chordin expression. The expression was induced by blockade of BMP4 signal. Overexpression of Zic3 resulted in hyperplastic neural and neural crest derived tissue. In animal cap explant, the overexpression of Zic3 induced expression of all the proneural genes and neural crest marker genes. These findings suggest that Zic3 can determine the ectodermal cell fate and promote the earliest step of neural and neural crest development.
PubMed ID: 9342348
PMC ID: PMC23676
Article link: Proc Natl Acad Sci U S A
Species referenced: Xenopus
Genes referenced: actl6a ascl2 bmp4 chrd.1 en2 h4c4 hoxa9 hoxb9 hoxc9 krt12.4 ncam1 neurod1 neurod4 neurog1 pou3f4 snai2 tbxt twist1 zic3
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References [+] :
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A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells.
1994, Pubmed
Aruga,
A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells.
1994,
Pubmed
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Fainsod, The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4. 1997, Pubmed , Xenbase
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Tanabe, Diversity and pattern in the developing spinal cord. 1996, Pubmed
Turner, Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. 1994, Pubmed , Xenbase
Wilson, Induction of epidermis and inhibition of neural fate by Bmp-4. 1995, Pubmed , Xenbase
Witta, XIPOU 2, a noggin-inducible gene, has direct neuralizing activity. 1995, Pubmed , Xenbase
Wright, The Xenopus XIHbox 6 homeo protein, a marker of posterior neural induction, is expressed in proliferating neurons. 1990, Pubmed , Xenbase
Xu, A dominant negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm. 1995, Pubmed , Xenbase
Yokota, Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma. 1996, Pubmed
Zimmerman, XASH-3, a novel Xenopus achaete-scute homolog, provides an early marker of planar neural induction and position along the mediolateral axis of the neural plate. 1994, Pubmed , Xenbase
Zimmerman, The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. 1996, Pubmed , Xenbase
Aruga, The mouse zic gene family. Homologues of the Drosophila pair-rule gene odd-paired. 1996, Pubmed
Aruga, Identification and characterization of Zic4, a new member of the mouse Zic gene family. 1996, Pubmed
Asashima, Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor). 2020, Pubmed , Xenbase
Bang, Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm. 1997, Pubmed , Xenbase
Benedyk, odd-paired: a zinc finger pair-rule protein required for the timely activation of engrailed and wingless in Drosophila embryos. 1994, Pubmed
Calof, Intrinsic and extrinsic factors regulating vertebrate neurogenesis. 1995, Pubmed
Chitnis, Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta. 1995, Pubmed , Xenbase
Chitnis, Sensitivity of proneural genes to lateral inhibition affects the pattern of primary neurons in Xenopus embryos. 1996, Pubmed , Xenbase
Cimbora, Drosophila midgut morphogenesis requires the function of the segmentation gene odd-paired. 1995, Pubmed
Eagleson, Mapping of the presumptive brain regions in the neural plate of Xenopus laevis. 1990, Pubmed , Xenbase
Fainsod, On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo. 1994, Pubmed , Xenbase
Fainsod, The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4. 1997, Pubmed , Xenbase
Ferreiro, XASH genes promote neurogenesis in Xenopus embryos. 1995, Pubmed , Xenbase
Godsave, Clonal analysis of mesoderm induction in Xenopus laevis. 1989, Pubmed , Xenbase
Grunz, Neural differentiation of Xenopus laevis ectoderm takes place after disaggregation and delayed reaggregation without inducer. 1990, Pubmed , Xenbase
Hansen, Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3. 1997, Pubmed , Xenbase
Hawley, Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. 1996, Pubmed , Xenbase
Hemmati-Brivanlou, Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. 1994, Pubmed , Xenbase
Hemmati-Brivanlou, Ventral mesodermal patterning in Xenopus embryos: expression patterns and activities of BMP-2 and BMP-4. 1995, Pubmed , Xenbase
Hemmati-Brivanlou, Cephalic expression and molecular characterization of Xenopus En-2. 1991, Pubmed , Xenbase
Hopwood, A Xenopus mRNA related to Drosophila twist is expressed in response to induction in the mesoderm and the neural crest. 1990, Pubmed , Xenbase
Jones, Development of the ectoderm in Xenopus: tissue specification and the role of cell association and division. 1986, Pubmed , Xenbase
Kelly, Histological preparation of Xenopus laevis oocytes and embryos. 1992, Pubmed , Xenbase
Kintner, Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction. 1987, Pubmed , Xenbase
Lamb, Neural induction by the secreted polypeptide noggin. 1993, Pubmed , Xenbase
Lee, Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. 1995, Pubmed , Xenbase
Liem, Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. 1995, Pubmed , Xenbase
Ma, Identification of neurogenin, a vertebrate neuronal determination gene. 1996, Pubmed , Xenbase
Mancilla, Neural crest formation in Xenopus laevis: mechanisms of Xslug induction. 1996, Pubmed , Xenbase
Mayor, Induction of the prospective neural crest of Xenopus. 1995, Pubmed , Xenbase
Nagai, The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation. 1997, Pubmed
Oschwald, Localization of a nervous system-specific class II beta-tubulin gene in Xenopus laevis embryos by whole-mount in situ hybridization. 1992, Pubmed , Xenbase
Piccolo, Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. 1996, Pubmed , Xenbase
Sasai, Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. 1995, Pubmed , Xenbase
Sasai, Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. 1995, Pubmed , Xenbase
Schmidt, Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo. 1995, Pubmed , Xenbase
Simpson, Positive and negative regulators of neural fate. 1995, Pubmed
Smith, A nodal-related gene defines a physical and functional domain within the Spemann organizer. 1995, Pubmed , Xenbase
Smith, Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. 1992, Pubmed , Xenbase
Suzuki, Autoinduction of activin genes in early Xenopus embryos. 1994, Pubmed , Xenbase
Takebayashi, Conversion of ectoderm into a neural fate by ATH-3, a vertebrate basic helix-loop-helix gene homologous to Drosophila proneural gene atonal. 1997, Pubmed , Xenbase
Tanabe, Diversity and pattern in the developing spinal cord. 1996, Pubmed
Turner, Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. 1994, Pubmed , Xenbase
Wilson, Induction of epidermis and inhibition of neural fate by Bmp-4. 1995, Pubmed , Xenbase
Witta, XIPOU 2, a noggin-inducible gene, has direct neuralizing activity. 1995, Pubmed , Xenbase
Wright, The Xenopus XIHbox 6 homeo protein, a marker of posterior neural induction, is expressed in proliferating neurons. 1990, Pubmed , Xenbase
Xu, A dominant negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm. 1995, Pubmed , Xenbase
Yokota, Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma. 1996, Pubmed
Zimmerman, XASH-3, a novel Xenopus achaete-scute homolog, provides an early marker of planar neural induction and position along the mediolateral axis of the neural plate. 1994, Pubmed , Xenbase
Zimmerman, The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. 1996, Pubmed , Xenbase