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XB-ART-46669
Nat Genet December 1, 2012; 44 (12): 1382-7.
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Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension.

Lienkamp SS , Liu K , Karner CM , Carroll TJ , Ronneberger O , Wallingford JB , Walz G .


Abstract
Cystic kidney diseases are a global public health burden, affecting over 12 million people. Although much is known about the genetics of kidney development and disease, the cellular mechanisms driving normal kidney tubule elongation remain unclear. Here, we used in vivo imaging to show for the first time that mediolaterally oriented cell intercalation is fundamental to vertebrate kidney morphogenesis. Unexpectedly, we found that kidney tubule elongation is driven in large part by a myosin-dependent, multicellular rosette-based mechanism, previously only described in Drosophila melanogaster. In contrast to findings in Drosophila, however, non-canonical Wnt and planar cell polarity (PCP) signaling is required to control rosette topology and orientation during vertebrate kidney tubule elongation. These data resolve long-standing questions concerning the role of PCP signaling in the developing kidney and, moreover, establish rosette-based intercalation as a deeply conserved cellular engine for epithelial morphogenesis.

PubMed ID: 23143599
PMC ID: PMC4167614
Article link: Nat Genet
Grant support: [+]

Species referenced: Xenopus
Genes referenced: ctnnb1 mlc1 wnt9b


Article Images: [+] show captions
References [+] :
Bertet, Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation. 2004, Pubmed