XB-ART-47456
Dev Dyn
2010 Jan 01;2391:77-93. doi: 10.1002/dvdy.22059.
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Wnt to build a tube: contributions of Wnt signaling to epithelial tubulogenesis.
Miller RK
,
McCrea PD
.
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Epithelial tubes are crucial to the function of organ systems including the cardiovascular system, pulmonary system, gastrointestinal tract, reproductive organ systems, excretory system, and auditory system. Using a variety of animal model systems, recent studies have substantiated the role of Wnt signaling via the canonical/beta-catenin-mediated trajectory, the non-canonical Wnt trajectories, or both, in forming epithelial tubular tissues. This review focuses on the involvement of the Wnt pathways in the induction, specification, proliferation, and morphogenesis involved in tubulogenesis within tissues including the lungs, kidneys, ears, mammary glands, gut, and heart. The ultimate goal is to describe the developmental processes forming the various tubulogenic organ systems to determine the relationships between these processes.
???displayArticle.pubmedLink??? 19681164
???displayArticle.pmcLink??? PMC3437621
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???displayArticle.grants??? [+]
F32 DK082145 NIDDK NIH HHS , F32 DK082145-02 NIDDK NIH HHS , R01 GM052112 NIGMS NIH HHS , R01 GM052112-15S1 NIGMS NIH HHS , T32 HD007325-24 NICHD NIH HHS , T32 HD07325 NICHD NIH HHS , F32 DK082145 NIDDK NIH HHS, F32 DK082145-02 NIDDK NIH HHS
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