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Biol Open April 24, 2015; 4 (6): 722-30.
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Planar polarization of Vangl2 in the vertebrate neural plate is controlled by Wnt and Myosin II signaling.

Ossipova O , Kim K , Sokol SY .

The vertebrate neural tube forms as a result of complex morphogenetic movements, which require the functions of several core planar cell polarity (PCP) proteins, including Vangl2 and Prickle. Despite the importance of these proteins for neurulation, their subcellular localization and the mode of action have remained largely unknown. Here we describe the anteroposterior planar cell polarity (AP-PCP) of the cells in the Xenopus neural plate. At the neural midline, the Vangl2 protein is enriched at anterior cell edges and that this localization is directed by Prickle, a Vangl2-interacting protein. Our further analysis is consistent with the model, in which Vangl2 AP-PCP is established in the neural plate as a consequence of Wnt-dependent phosphorylation. Additionally, we uncover feedback regulation of Vangl2 polarity by Myosin II, reiterating a role for mechanical forces in PCP. These observations indicate that both Wnt signaling and Myosin II activity regulate cell polarity and cell behaviors during vertebrate neurulation.

PubMed ID: 25910938
PMC ID: PMC4467192
Article link: Biol Open
Grant support: [+]

Species referenced: Xenopus
Genes referenced: actl6a ctnnb1 pkm ppp1r12a prickle1 tjp1 vangl2 wnt5a
Antibodies: Vangl2 Ab4

Article Images: [+] show captions
References [+] :
Adler, The frizzled/stan pathway and planar cell polarity in the Drosophila wing. 2012, Pubmed