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Int J Dev Biol January 1, 2016; 60 (4-6): 159-66.
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Genes regulated by potassium channel tetramerization domain containing 15 (Kctd15) in the developing neural crest.

Wong TC , Rebbert M , Wang C , Chen X , Heffer A , Zarelli VE , Dawid IB , Zhao H .

Neural crest (NC) development is controlled precisely by a regulatory network with multiple signaling pathways and the involvement of many genes. The integration and coordination of these factors are still incompletely understood. Overexpression of Wnt3a and the BMP antagonist Chordin in animal cap cells from Xenopus blastulae induces a large number of NC specific genes. We previously suggested that Potassium Channel Tetramerization Domain containing 15 (Kctd15) regulates NC formation by affecting Wnt signaling and the activity of transcription factor AP-2. In order to advance understanding of the function of Kctd15 during NC development, we performed DNA microarray assays in explants injected with Wnt3a and Chordin, and identified genes that are affected by Kctd15 overexpression. Among the many genes identified, we chose Duf domain containing protein 1 (ddcp1), Platelet-Derived Growth Factor Receptor a (pdgfra), Complement factor properdin (cfp), Zinc Finger SWIM-Type Containing 5 (zswim5), and complement component 3 (C3) to examine their expression by whole mount in situ hybridization. Our work points to a possible role for Kctd15 in the regulation of NC formation and other steps in embryonic development.

PubMed ID: 27389986
PMC ID: PMC4987960
Article link: Int J Dev Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: c3 cfp chrd.1 foxd3 kctd15 kiaa1210 lmx1b.1 pax3 pdgfra snai2 sox10 sox8 sox9 tfap2e twist1 wnt3a zic1 zswim4
GO keywords: neural crest cell development

GEO Series: GSE72391: NCBI

Article Images: [+] show captions
References [+] :
Ali, Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection. 2014, Pubmed