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Genesis January 1, 2017; 55 (1-2):

Xenopus laevis as a model system to study cytoskeletal dynamics during axon pathfinding.

The model system, Xenopus laevis, has been used in innumerable research studies and has contributed to the understanding of multiple cytoskeletal components, including actin, microtubules, and neurofilaments, during axon pathfinding. Xenopus developmental stages have been widely characterized, and the Xenopus genome has been sequenced, allowing gene expression modifications through exogenous molecules. Xenopus cell cultures are ideal for long periods of live imaging because they are easily obtained and maintained, and they do not require special culture conditions. In addition, Xenopus have relatively large growth cones, compared to other vertebrates, thus providing a suitable system for imaging cytoskeletal components. Therefore, X. laevis is an ideal model organism in which to study cytoskeletal dynamics during axon pathfinding.

PubMed ID: 28095612
PMC ID: PMC5276718
Article link: Genesis
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: cdc42 clasp1 rac1 vav2

Article Images: [+] show captions
References [+] :
Andersen, Axon formation: a molecular model for the generation of neuronal polarity. 2000, Pubmed