XB-ART-8703Genes Dev July 15, 2001; 15 (14): 1765-70.
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MAD2B is an inhibitor of the anaphase-promoting complex.
Anaphase-promoting complex (APC), a ubiquitin ligase, controls both sister chromatid separation and mitotic exit. The APC is activated in mitosis and G1 by CDC20 and CDH1, and inhibited by the checkpoint protein MAD2, a specific inhibitor of CDC20. We show here that a MAD2 homolog MAD2B also inhibits APC. In contrast to MAD2, MAD2B inhibits both CDH1-APC and CDC20-APC. This inhibition is targeted to CDH1 and CDC20, but not directly to APC. Unlike MAD2, whose interaction with MAD1 is required for mitotic checkpoint control, MAD2B does not interact with MAD1, suggesting that MAD2B may relay a different cellular signal to APC.
PubMed ID: 11459826
PMC ID: PMC312737
Article link: Genes Dev
Species referenced: Xenopus
Genes referenced: cdc20 cdh1 mad2l1 mad2l2 mxd1
References [+] :
Amon, Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle. 1994, Pubmed