Griffin C , Saint-Jeannet JP .

F32 DE030699 NIDCR NIH HHS, R01 DE025806 NIDCR NIH HHS

             neural crest cell fate specification
             Wnt signaling pathway
             BMP signaling pathway
             retinoic acid receptor signaling pathway

Ahrens, Tissues and signals involved in the induction of placodal Six1 expression in Xenopus laevis. 2005, Pubmed, Xenbase

Ahrens, Tissues and signals involved in the induction of placodal Six1 expression in Xenopus laevis. 2005, Pubmed , Xenbase
Bailey, Lens specification is the ground state of all sensory placodes, from which FGF promotes olfactory identity. 2006, Pubmed
Baker, Vertebrate cranial placodes I. Embryonic induction. 2001, Pubmed , Xenbase
Bermingham-McDonogh, Regulated reprogramming in the regeneration of sensory receptor cells. 2011, Pubmed
Bhasin, Mesenchymal/epithelial regulation of retinoic acid signaling in the olfactory placode. 2003, Pubmed
Bhat, A gene network that coordinates preplacodal competence and neural crest specification in zebrafish. 2013, Pubmed
Bhattacharyya, Segregation of lens and olfactory precursors from a common territory: cell sorting and reciprocity of Dlx5 and Pax6 expression. 2004, Pubmed
Birol, The mouse Foxi3 transcription factor is necessary for the development of posterior placodes. 2016, Pubmed
Boesveldt, Anosmia-A Clinical Review. 2017, Pubmed
Bricker, A Molecular Analysis of Neural Olfactory Placode Differentiation in Human Pluripotent Stem Cells. 2022, Pubmed
Brigande, Quo vadis, hair cell regeneration? 2009, Pubmed
Brugmann, Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. 2004, Pubmed , Xenbase
Brugmann, Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs. 2005, Pubmed , Xenbase
Canning, Neural tube derived Wnt signals cooperate with FGF signaling in the formation and differentiation of the trigeminal placodes. 2008, Pubmed
Carter, Olfactory horizontal basal cells demonstrate a conserved multipotent progenitor phenotype. 2004, Pubmed
Chapman, Expression analysis of chick Wnt and frizzled genes and selected inhibitors in early chick patterning. 2004, Pubmed , Xenbase
Chen, A concentration gradient of retinoids in the early Xenopus laevis embryo. 1994, Pubmed , Xenbase
Chen, Increased XRALDH2 activity has a posteriorizing effect on the central nervous system of Xenopus embryos. 2001, Pubmed , Xenbase
Chen, Restoration of auditory evoked responses by human ES-cell-derived otic progenitors. 2012, Pubmed
Chen, Induction of the inner ear: stepwise specification of otic fate from multipotent progenitors. 2013, Pubmed
Choi, Olfactory epithelium: Cells, clinical disorders, and insights from an adult stem cell niche. 2018, Pubmed
Chow, Early eye development in vertebrates. 2001, Pubmed
Christophorou, Activation of Six1 target genes is required for sensory placode formation. 2009, Pubmed
Culbertson, Chondrogenic and gliogenic subpopulations of neural crest play distinct roles during the assembly of epibranchial ganglia. 2011, Pubmed
De Robertis, Dorsal-ventral patterning and neural induction in Xenopus embryos. 2004, Pubmed , Xenbase
DeHamer, Genesis of olfactory receptor neurons in vitro: regulation of progenitor cell divisions by fibroblast growth factors. 1994, Pubmed
Devotta, Npr3 regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor. 2023, Pubmed , Xenbase
Dewi, A simplified method for producing human lens epithelial cells and light-focusing micro-lenses from pluripotent stem cells. 2021, Pubmed
Dincer, Specification of functional cranial placode derivatives from human pluripotent stem cells. 2013, Pubmed
Doda, Human pluripotent stem cell-derived inner ear organoids recapitulate otic development in vitro. 2023, Pubmed
Dubey, Generating retinoic acid gradients by local degradation during craniofacial development: One cell's cue is another cell's poison. 2018, Pubmed
Duggan, Foxg1 is required for development of the vertebrate olfactory system. 2008, Pubmed
Dutta, pitx3 defines an equivalence domain for lens and anterior pituitary placode. 2005, Pubmed
Ealy, Single-cell analysis delineates a trajectory toward the human early otic lineage. 2016, Pubmed
Edlund, Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. 2014, Pubmed
Ericson, Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. 1998, Pubmed
Esterberg, dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity. 2009, Pubmed
Freter, Progressive restriction of otic fate: the role of FGF and Wnt in resolving inner ear potential. 2008, Pubmed
Fu, Generation of Functional Lentoid Bodies From Human Induced Pluripotent Stem Cells Derived From Urinary Cells. 2017, Pubmed
Gabriel, Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia. 2023, Pubmed
García-Castro, Ectodermal Wnt function as a neural crest inducer. 2002, Pubmed
Givens, Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. 2005, Pubmed
Glavic, Role of BMP signaling and the homeoprotein Iroquois in the specification of the cranial placodal field. 2004, Pubmed , Xenbase
Glenn Northcutt, The new head hypothesis revisited. 2005, Pubmed
Goudreau, Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. 2002, Pubmed
Grocott, The peripheral sensory nervous system in the vertebrate head: a gene regulatory perspective. 2012, Pubmed
Groves, Competence, specification and commitment in otic placode induction. 2000, Pubmed , Xenbase
Groves, Shaping sound in space: the regulation of inner ear patterning. 2012, Pubmed
Groves, Setting appropriate boundaries: fate, patterning and competence at the neural plate border. 2014, Pubmed , Xenbase
Gunewardene, Directing human induced pluripotent stem cells into a neurosensory lineage for auditory neuron replacement. 2014, Pubmed
Hans, Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors. 2004, Pubmed
Hans, Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. 2007, Pubmed
Hemmati-Brivanlou, Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. 1994, Pubmed , Xenbase
Hong, The activity of Pax3 and Zic1 regulates three distinct cell fates at the neural plate border. 2007, Pubmed , Xenbase
Iyer, Enhancers of GnRH transcription embedded in an upstream gene use homeodomain proteins to specify hypothalamic expression. 2010, Pubmed
Karlstrom, Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning. 1999, Pubmed
Kawauchi, Molecular signals regulating proliferation of stem and progenitor cells in mouse olfactory epithelium. 2004, Pubmed
Kelberman, Genetic regulation of pituitary gland development in human and mouse. 2009, Pubmed
Khatri, Foxi3 is necessary for the induction of the chick otic placode in response to FGF signaling. 2014, Pubmed
Khudyakov, Comprehensive spatiotemporal analysis of early chick neural crest network genes. 2009, Pubmed
Kil, Distinct roles for hindbrain and paraxial mesoderm in the induction and patterning of the inner ear revealed by a study of vitamin-A-deficient quail. 2005, Pubmed
Kim, Congenital Hypogonadotropic Hypogonadism and Kallmann Syndrome: Past, Present, and Future. 2015, Pubmed
Kobayashi, Expression of three zebrafish Six4 genes in the cranial sensory placodes and the developing somites. 2000, Pubmed
Kobayashi, The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation. 2001, Pubmed
Koehler, Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture. 2013, Pubmed
Koehler, Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells. 2017, Pubmed
Koontz, Making a head: Neural crest and ectodermal placodes in cranial sensory development. 2023, Pubmed
Kozlowski, Regional cell movement and tissue patterning in the zebrafish embryo revealed by fate mapping with caged fluorescein. 1997, Pubmed
Kwon, Identification of early requirements for preplacodal ectoderm and sensory organ development. 2010, Pubmed
LaBonne, Neural crest induction in Xenopus: evidence for a two-signal model. 1998, Pubmed , Xenbase
LaMantia, Mesenchymal/epithelial induction mediates olfactory pathway formation. 2000, Pubmed
Ladher, Identification of synergistic signals initiating inner ear development. 2000, Pubmed
Ladher, FGF8 initiates inner ear induction in chick and mouse. 2005, Pubmed
Lahlou, Modeling human early otic sensory cell development with induced pluripotent stem cells. 2018, Pubmed
Larraín, BMP-binding modules in chordin: a model for signalling regulation in the extracellular space. 2000, Pubmed , Xenbase
Lassiter, Canonical Wnt signaling is required for ophthalmic trigeminal placode cell fate determination and maintenance. 2007, Pubmed
Lassiter, Sensory neuron differentiation is regulated by notch signaling in the trigeminal placode. 2010, Pubmed
Lassiter, Signaling mechanisms controlling cranial placode neurogenesis and delamination. 2014, Pubmed
Li, Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. 2003, Pubmed
Litsiou, A balance of FGF, BMP and WNT signalling positions the future placode territory in the head. 2005, Pubmed
Liu, Characterization of the functionally related sites in the neural inducing gene noggin. 2000, Pubmed , Xenbase
Liu, Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. 2006, Pubmed
Lleras-Forero, Neuropeptides: developmental signals in placode progenitor formation. 2013, Pubmed
Lund, Development of Gonadotropin-Releasing Hormone-Secreting Neurons from Human Pluripotent Stem Cells. 2016, Pubmed
Lunn, A spatial and temporal map of FGF/Erk1/2 activity and response repertoires in the early chick embryo. 2007, Pubmed
Luo, Induction of neural crest in Xenopus by transcription factor AP2alpha. 2003, Pubmed , Xenbase
Manni, Neurogenic and non-neurogenic placodes in ascidians. 2004, Pubmed
Matsuoka, Directed Differentiation of Human Embryonic Stem Cells Toward Placode-Derived Spiral Ganglion-Like Sensory Neurons. 2017, Pubmed
Mazet, Molecular evidence from Ciona intestinalis for the evolutionary origin of vertebrate sensory placodes. 2005, Pubmed
McCabe, Essential role for PDGF signaling in ophthalmic trigeminal placode induction. 2008, Pubmed
McCarroll, Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish. 2013, Pubmed
McLarren, DLX5 positions the neural crest and preplacode region at the border of the neural plate. 2003, Pubmed
Mengarelli, Derivation of multiple cranial tissues and isolation of lens epithelium-like cells from human embryonic stem cells. 2013, Pubmed
Monsoro-Burq, Neural crest induction by paraxial mesoderm in Xenopus embryos requires FGF signals. 2003, Pubmed , Xenbase
Moody, Transcriptional regulation of cranial sensory placode development. 2015, Pubmed
Nechiporuk, Endoderm-derived Fgf3 is necessary and sufficient for inducing neurogenesis in the epibranchial placodes in zebrafish. 2005, Pubmed
Nie, Generation of inner ear organoids from human pluripotent stem cells. 2020, Pubmed
Nie, CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids. 2022, Pubmed
Ogita, Expression of the Dan gene during chicken embryonic development. 2001, Pubmed , Xenbase
Ohnishi, Limited hair cell induction from human induced pluripotent stem cells using a simple stepwise method. 2015, Pubmed
Ohyama, Wnt signals mediate a fate decision between otic placode and epidermis. 2006, Pubmed
Ozone, Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells. 2016, Pubmed
Padanad, Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24. 2011, Pubmed
Papanayotou, A mechanism regulating the onset of Sox2 expression in the embryonic neural plate. 2008, Pubmed
Park, Hindbrain-derived Wnt and Fgf signals cooperate to specify the otic placode in Xenopus. 2008, Pubmed , Xenbase
Patthey, Early development of the central and peripheral nervous systems is coordinated by Wnt and BMP signals. 2008, Pubmed
Patthey, The evolutionary history of vertebrate cranial placodes--I: cell type evolution. 2014, Pubmed , Xenbase
Phillips, Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development. 2006, Pubmed
Piccolo, The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. 1999, Pubmed , Xenbase
Pieper, Origin and segregation of cranial placodes in Xenopus laevis. 2011, Pubmed , Xenbase
Pieper, Differential distribution of competence for panplacodal and neural crest induction to non-neural and neural ectoderm. 2012, Pubmed , Xenbase
Purcell, Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. 2005, Pubmed
Regal, Prevalence and incidence of hypopituitarism in an adult Caucasian population in northwestern Spain. 2001, Pubmed
Rizzoti, Genetic regulation of murine pituitary development. 2015, Pubmed
Roellig, Dynamic transcriptional signature and cell fate analysis reveals plasticity of individual neural plate border cells. 2017, Pubmed
Rogers, The response of early neural genes to FGF signaling or inhibition of BMP indicate the absence of a conserved neural induction module. 2011, Pubmed , Xenbase
Saint-Jeannet, Establishing the pre-placodal region and breaking it into placodes with distinct identities. 2014, Pubmed , Xenbase
Saint-Jeannet, Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a. 1997, Pubmed , Xenbase
Sato, Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR. 2010, Pubmed , Xenbase
Schlosser, Hypobranchial placodes in Xenopus laevis give rise to hypobranchial ganglia, a novel type of cranial ganglia. 2003, Pubmed , Xenbase
Schlosser, Making senses development of vertebrate cranial placodes. 2010, Pubmed , Xenbase
Schlosser, Molecular anatomy of placode development in Xenopus laevis. 2004, Pubmed , Xenbase
Schlosser, Development of neurogenic placodes in Xenopus laevis. 2000, Pubmed , Xenbase
Sheng, Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. 1996, Pubmed
Sheng, Multistep control of pituitary organogenesis. 1997, Pubmed
Shigetani, Wise promotes coalescence of cells of neural crest and placode origins in the trigeminal region during head development. 2008, Pubmed
Singh, The molecular basis of craniofacial placode development. 2016, Pubmed
Sjödal, Time of exposure to BMP signals plays a key role in the specification of the olfactory and lens placodes ex vivo. 2007, Pubmed
Smith, Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis. 2009, Pubmed
Solomon, Genetic interactions underlying otic placode induction and formation. 2004, Pubmed
Stark, Neural tube-ectoderm interactions are required for trigeminal placode formation. 1997, Pubmed
Steventon, Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning. 2012, Pubmed , Xenbase
Streit, Extensive cell movements accompany formation of the otic placode. 2002, Pubmed
Streit, Early development of the cranial sensory nervous system: from a common field to individual placodes. 2004, Pubmed
Streit, The preplacodal region: an ectodermal domain with multipotential progenitors that contribute to sense organs and cranial sensory ganglia. 2007, Pubmed
Streit, Establishment and maintenance of the border of the neural plate in the chick: involvement of FGF and BMP activity. 1999, Pubmed
Streit, Initiation of neural induction by FGF signalling before gastrulation. 2000, Pubmed
Sun, Epibranchial and otic placodes are induced by a common Fgf signal, but their subsequent development is independent. 2007, Pubmed
Sánchez-Arrones, Origin and early development of the chicken adenohypophysis. 2015, Pubmed
Takahashi, Induction of pluripotent stem cells from adult human fibroblasts by defined factors. 2007, Pubmed
Tchieu, A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages. 2017, Pubmed
Thiery, scRNA-sequencing in chick suggests a probabilistic model for cell fate allocation at the neural plate border. 2023, Pubmed
Treier, Multistep signaling requirements for pituitary organogenesis in vivo. 1998, Pubmed
Ueda, Directed Differentiation of Human Pluripotent Stem Cells into Inner Ear Organoids. 2022, Pubmed
Ueda, Defining developmental trajectories of prosensory cells in human inner ear organoids at single-cell resolution. 2023, Pubmed
Voelkel, FGF and Notch signaling in sensory neuron formation: a multifactorial approach to understanding signaling pathway hierarchy. 2014, Pubmed
Wakamatsu, Mutual repression between Pax3 and Pax6 is involved in the positioning of ophthalmic trigeminal placode in avian embryo. 2011, Pubmed
Whitlock, The olfactory placodes of the zebrafish form by convergence of cellular fields at the edge of the neural plate. 2000, Pubmed
Williams, Single-cell atlas of early chick development reveals gradual segregation of neural crest lineage from the neural plate border during neurulation. 2022, Pubmed
Wilson, An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo. 2000, Pubmed , Xenbase
Wright, Fgf3 and Fgf10 are required for mouse otic placode induction. 2003, Pubmed
Xu, Fine-grained fate maps for the ophthalmic and maxillomandibular trigeminal placodes in the chick embryo. 2008, Pubmed
Yang, An early phase of embryonic Dlx5 expression defines the rostral boundary of the neural plate. 1998, Pubmed
Yang, Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions. 2010, Pubmed
Zelarayan, Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. 2007, Pubmed
Zimmer, Derivation of Diverse Hormone-Releasing Pituitary Cells from Human Pluripotent Stem Cells. 2016, Pubmed
Zimmerman, The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. 1996, Pubmed , Xenbase
Zou, Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. 2004, Pubmed
van der Valk, A single-cell level comparison of human inner ear organoids with the human cochlea and vestibular organs. 2023, Pubmed