Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
EMBO J 1995 Dec 15;1424:6268-79. doi: 10.1002/j.1460-2075.1995.tb00317.x.
Show Gene links Show Anatomy links

Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1.

Gawantka V , Delius H , Hirschfeld K , Blumenstock C , Niehrs C .

We have identified a novel homeobox gene, Xvent-1, that is differentially expressed in the ventral marginal zone of the early Xenopus gastrula. Evidence is presented from mRNA microinjection experiments for a role for this gene in dorsoventral patterning of mesoderm. First, Xvent-1 is induced by BMP-4, a gene known to be a key regulator of ventral mesoderm development. Second, Xvent-1 and the organizer-specific gene goosecoid are able to interact, directly or indirectly, in a cross-regulatory loop suppressing each other's expression, consistent with their mutually exclusive expression in the marginal zone. Third, microinjection of Xvent-1 mRNA ventralizes dorsal mesoderm. The results suggest that Xvent-1 functions in a ventral signaling pathway that maintains the ventral mesodermal state and antagonizes the Spemann organizer.

PubMed ID: 8557046
PMC ID: PMC394751
Article link: EMBO J

Species referenced: Xenopus
Genes referenced: gsc ventx1.2

References [+] :
Amaya, FGF signalling in the early specification of mesoderm in Xenopus. 1993, Pubmed, Xenbase