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Histochem Cell Biol
2007 Feb 01;1272:139-48. doi: 10.1007/s00418-006-0231-0.
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Nuclear myosin is ubiquitously expressed and evolutionary conserved in vertebrates.
Kahle M
,
Pridalová J
,
Spacek M
,
Dzijak R
,
Hozák P
.
Abstract
Nuclear myosin I (NMI) is a single-headed member of myosin superfamily localized in the cell nucleus which participates along with nuclear actin in transcription and chromatin remodeling. We demonstrate that NMI is present in cell nuclei of all mouse tissues examined except for cells in terminal stages of spermiogenesis. Quantitative PCR and western blots demonstrate that the expression of NMI in tissues varies with the highest levels in the lungs. The expression of NMI is lower in serum-starved cells and it increases after serum stimulation. The lifespan of NMI is longer than 16 h as determined by cycloheximide translation block. A homologous protein is expressed in human, chicken, Xenopus, and zebrafish as shown by RACE analysis. The analysis of genomic sequences indicates that almost identical homologous NMI genes are expressed in mammals, and similar NMI genes in vertebrates.
Altschul,
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
1997, Pubmed
Altschul,
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
1997,
Pubmed
Burge,
Prediction of complete gene structures in human genomic DNA.
1997,
Pubmed
Cavellán,
The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.
2006,
Pubmed
Chuang,
Long-range directional movement of an interphase chromosome site.
2006,
Pubmed
Crozet,
Cloning of the genes encoding two murine and human cochlear unconventional type I myosins.
1997,
Pubmed
Fomproix,
An actin-myosin complex on actively transcribing genes.
2004,
Pubmed
Gillespie,
Myosin-1c, the hair cell's adaptation motor.
2004,
Pubmed
Gonda,
Universality and structure of the N-end rule.
1989,
Pubmed
Grummt,
Actin and myosin as transcription factors.
2006,
Pubmed
Iyer,
The transcriptional program in the response of human fibroblasts to serum.
1999,
Pubmed
Jaillon,
Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype.
2004,
Pubmed
Kumar,
MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment.
2004,
Pubmed
Kyselá,
Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell.
2005,
Pubmed
Livak,
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
2002,
Pubmed
Percipalle,
The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription.
2006,
Pubmed
Percipalle,
Chromatin remodelling and transcription: be-WICHed by nuclear myosin 1.
2006,
Pubmed
Pestic-Dragovich,
A myosin I isoform in the nucleus.
2000,
Pubmed
Philimonenko,
Nuclear actin and myosin I are required for RNA polymerase I transcription.
2004,
Pubmed
Rossini,
High-resolution sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunochemical identification of the 2X and embryonic myosin heavy chains in complex mixtures of isomyosins.
1995,
Pubmed
Ruppert,
Localization of the rat myosin I molecules myr 1 and myr 2 and in vivo targeting of their tail domains.
1997,
Pubmed
Sherr,
Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family.
1993,
Pubmed
Wagner,
Tissue distribution and subcellular localization of mammalian myosin I.
1992,
Pubmed
,
Xenbase
Williams,
Phosphorylation of myosin-I from rat liver by protein kinase C reduces calmodulin binding.
1995,
Pubmed
Yanai,
Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification.
2005,
Pubmed
Yildirim,
The role of protein secretion on the adhesion strength of Chinese hamster lung (CHL) cells.
1998,
Pubmed
Zhu,
High affinity Ca2+ binding sites of calmodulin are critical for the regulation of myosin Ibeta motor function.
1998,
Pubmed
de Lanerolle,
Actin and myosin I in the nucleus: what next?
2005,
Pubmed
