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Development 2008 Jan 01;1352:333-42. doi: 10.1242/dev.009563.
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A role for S1P signalling in axon guidance in the Xenopus visual system.

Strochlic L , Dwivedy A , van Horck FP , Falk J , Holt CE .

Sphingosine 1-phosphate (S1P), a lysophospholipid, plays an important chemotactic role in the migration of lymphocytes and germ cells, and is known to regulate aspects of central nervous system development such as neurogenesis and neuronal migration. Its role in axon guidance, however, has not been examined. We show that sphingosine kinase 1, an enzyme that generates S1P, is expressed in areas surrounding the Xenopus retinal axon pathway, and that gain or loss of S1P function in vivo causes errors in axon navigation. Chemotropic assays reveal that S1P elicits fast repulsive responses in retinal growth cones. These responses require heparan sulfate, are sensitive to inhibitors of proteasomal degradation, and involve RhoA and LIM kinase activation. Together, the data identify downstream components that mediate S1P-induced growth cone responses and implicate S1P signalling in axon guidance.

PubMed ID: 18077591
PMC ID: PMC3682207
Article link: Development
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: rhoa s1pr5 sphk1 tec

Article Images: [+] show captions
References [+] :
Aizawa, Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. 2001, Pubmed