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Semin Cell Dev Biol 2015 Jun 01;42:78-85. doi: 10.1016/j.semcdb.2015.05.002.
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Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development.

Wnt signaling pathways act at multiple locations and developmental stages to specify cell fate and polarity in vertebrate embryos. A long-standing question is how the same molecular machinery can be reused to produce different outcomes. The canonical Wnt/β-catenin branch modulates target gene transcription to specify cell fates along the dorsoventral and anteroposterior embryonic axes. By contrast, the Wnt/planar cell polarity (PCP) branch is responsible for cell polarization along main body axes, which coordinates morphogenetic cell behaviors during gastrulation and neurulation. Whereas both cell fate and cell polarity are modulated by spatially- and temporally-restricted Wnt activity, the downstream signaling mechanisms are very diverse. This review highlights recent progress in the understanding of Wnt-dependent molecular events leading to the establishment of PCP and linking it to early morphogenetic processes.

PubMed ID: 25986055
PMC ID: PMC4562884
Article link: Semin Cell Dev Biol
Grant support: [+]

Species referenced: Xenopus
Genes referenced: ankrd6 axin1 ctnnb1 daam1 dvl1 fuz fzd1 gsk3b intu lrp5 lrp6 prickle1 rab11a rhoa rock1 ror2 tcf7 tcf7l1 tjp1 vangl2 wnt1

Article Images: [+] show captions
References [+] :
Acebron, Mitotic wnt signaling promotes protein stabilization and regulates cell size. 2014, Pubmed