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Int J Mol Sci 2018 Oct 30;1911:. doi: 10.3390/ijms19113390.
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Calcium Signaling in Vertebrate Development and Its Role in Disease.

Paudel S , Sindelar R , Saha M .

Accumulating evidence over the past three decades suggests that altered calcium signaling during development may be a major driving force for adult pathophysiological events. Well over a hundred human genes encode proteins that are specifically dedicated to calcium homeostasis and calcium signaling, and the majority of these are expressed during embryonic development. Recent advances in molecular techniques have identified impaired calcium signaling during development due to either mutations or dysregulation of these proteins. This impaired signaling has been implicated in various human diseases ranging from cardiac malformations to epilepsy. Although the molecular basis of these and other diseases have been well studied in adult systems, the potential developmental origins of such diseases are less well characterized. In this review, we will discuss the recent evidence that examines different patterns of calcium activity during early development, as well as potential medical conditions associated with its dysregulation. Studies performed using various model organisms, including zebrafish, Xenopus, and mouse, have underscored the critical role of calcium activity in infertility, abortive pregnancy, developmental defects, and a range of diseases which manifest later in life. Understanding the underlying mechanisms by which calcium regulates these diverse developmental processes remains a challenge; however, this knowledge will potentially enable calcium signaling to be used as a therapeutic target in regenerative and personalized medicine.

PubMed ID: 30380695
PMC ID: PMC6274931
Article link: Int J Mol Sci
Grant support: [+]

Species referenced: Xenopus
Genes referenced: atp2a2 atp2a3 cacna1a cacna1b cacna1c cacna1d cacna1f cacna1g cacna1h cacna1i cacna1s itpr1 orai2 p2ry1 p2ry11 p2ry2 p2ry4 ryr1 ryr3 stim1 trpc1 trpc2 trpm6 trpm7 trpv1 trpv2 trpv3 trpv4 trpv5 trpv6
GO keywords: calcium channel activity

Article Images: [+] show captions
References [+] :
Abdul-Wajid, T-type Calcium Channel Regulation of Neural Tube Closure and EphrinA/EPHA Expression. 2015, Pubmed, Xenbase