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Genes (Basel) 2019 Nov 06;1011:. doi: 10.3390/genes10110895.
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Repression of Inappropriate Gene Expression in the Vertebrate Embryonic Ectoderm.

Reich S , Weinstein DC .

During vertebrate embryogenesis, precise regulation of gene expression is crucial for proper cell fate determination. Much of what we know about vertebrate development has been gleaned from experiments performed on embryos of the amphibian Xenopus laevis; this review will focus primarily on studies of this model organism. An early critical step during vertebrate development is the formation of the three primary germ layers-ectoderm, mesoderm, and endoderm-which emerge during the process of gastrulation. While much attention has been focused on the induction of mesoderm and endoderm, it has become clear that differentiation of the ectoderm involves more than the simple absence of inductive cues; rather, it additionally requires the inhibition of mesendoderm-promoting genes. This review aims to summarize our current understanding of the various inhibitors of inappropriate gene expression in the presumptive ectoderm.

PubMed ID: 31698780
PMC ID: PMC6895975
Article link: Genes (Basel)
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: ascl1 bambi chrd cripto.3 dand5 foxh1.2 foxi1 gmnn gsc hdac1 ndp nodal smad2 smad3 smad4 smad7 smurf2 srf tbx2 tbxt tmeff1 tp53 trim33 vegt wnt8a znf585b
GO keywords: gastrulation

Article Images: [+] show captions
References [+] :
Amaya, FGF signalling in the early specification of mesoderm in Xenopus. 1993, Pubmed, Xenbase