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Dev Dyn 2008 May 01;2375:1243-54. doi: 10.1002/dvdy.21517.
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The role of FGF signaling in the establishment and maintenance of mesodermal gene expression in Xenopus.

Fletcher RB , Harland RM .

FGF signaling is important for the formation of mesoderm in vertebrates, and when it is perturbed in Xenopus, most trunk and tail mesoderm fails to form. Here we have further dissected the activities of FGF in patterning the embryo by addressing its inductive and maintenance roles. We show that FGF signaling is necessary for the establishment of xbra expression in addition to its well-characterized role in maintaining xbra expression. The role of FGF signaling in organizer formation is not clear in Xenopus. We find that FGF signaling is essential for the initial specification of paraxial mesoderm but not for activation of several pan-mesodermal and most organizer genes; however, early FGF signaling is necessary for the maintenance of organizer gene expression into the neurula stage. Inhibition of FGF signaling prevents VegT activation of specific mesodermal transcripts. These findings illuminate how FGF signaling contributes to the establishment of distinct types of mesoderm.

PubMed ID: 18386826
PMC ID: PMC3000043
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: a2m bix1.3 chrd crx eomes fgf4 fgf8 fgfr1 gal.2 gsc myf5 myod1 nodal3.1 nog odc1 otx2 sox17a sox17b.1 sox2 tbxt vegt

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References [+] :
Agius, Endodermal Nodal-related signals and mesoderm induction in Xenopus. 2000, Pubmed, Xenbase