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J Neurosci 2006 Mar 08;2610:2820-9. doi: 10.1523/JNEUROSCI.5037-05.2006.
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RE-1 silencer of transcription/neural restrictive silencer factor modulates ectodermal patterning during Xenopus development.

Olguín P , Oteíza P , Gamboa E , Gómez-Skármeta JL , Kukuljan M .

RE-1 silencer of transcription/neural restrictive silencer factor (REST/NRSF), a transcriptional repressor, binds to the RE-1 element present in many vertebrate genes. In vitro studies indicate that REST/NRSF plays important roles in several stages of neural development. However, a full understanding of its physiological function requires in vivo approaches. We find that impairment of REST/NRSF function in Xenopus embryos leads to the perturbation of neural tube, cranial ganglia, and eye development. The origin of these defects is the abnormal patterning of the ectoderm during gastrulation. Interference of REST/NRSF function during the late blastula stage leads to an expansion of the neural plate, concomitant with a decrease of the expression of epidermal keratin and neural crest markers. Furthermore, neurogenesis proceeds abnormally, with loss of the expression of proneural, neurogenic, and neuronal genes. The interference of REST/NRSF mimics several features associated with a decreased bone morphogenetic protein (BMP) function and counteracts some effects of BMP4 misexpression. Our results indicate that REST/NRSF function is required in vivo for the acquisition of specific ectodermal cell fates.

PubMed ID: 16525062
PMC ID: PMC6675167
Article link: J Neurosci

Species referenced: Xenopus
Genes referenced: bmp4 dll1 hes1 krt12.4 msx1 nav1 neurog2 notch1 rest scn2a snai2 sox15 sox2 stmn2 tubb2b zic2
GO keywords: neural plate development [+]
Morpholinos: rest MO1

Article Images: [+] show captions
References [+] :
Andrés, CoREST: a functional corepressor required for regulation of neural-specific gene expression. 1999, Pubmed