Figure 5. Model for the modulation of Wnt/β-catenin pathway by extracellular domains of Frizzled receptors. We propose that a complex formed between Xfz4S and Wnt-3a/-8/-8b could be recognized by LRP and Wnt signaling could be activated in LRP dependent manner. Complexes between Xfz4S and Wnt-4/-5a/-11 would not be recognized by LRP and Xfz4S and Wnt/β-catenin signaling would not be activated by these Wnts.
Image published in: Swain RK et al. (2005)
Copyright © 2005 Swain et al; licensee BioMed Central Ltd. Creative Commons Attribution license
Permanent Image Page
Printer Friendly View
XB-IMG-116633