Figure 3. Ionic strength-dependent TEA block of Kv2.1 channels. Top, Raw currents as indicated in response to step depolarizations of 80 ms to −20, 0, +20 and +40 mV from a −80-mV holding voltage. Calibration, 2 μA, 20 ms. Bottom, Dose-response relation for TEA block of current at +40 mV in normal- (■) and low- (○) ionic strength solutions. Mean values from 4–10 measurements and SEM limits (if larger than symbols) are plotted. Line is a fit of equation 1 to the pooled normal- and low-ionic strength data with Kapp and Bmax values of 5.1 mM and 0.83, respectively.
Image published in: Quinn CC and Begenisich T (2006)
Image downloaded from an Open Access article in PubMed Central. © Springer Science+Business Media, Inc. 2007
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