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Figure 4. Gating parameters of S1 tryptophan scan. Changes of empirical gating parameters resulting from point Trp mutations are displayed versus residue number. (A) Intrinsic free energy of open-state stabilization, ΔΔGo. The shaded region (|ΔΔGo| < 1 kcal/mol) represents the range of values defining tolerant residues. (B and C) Mutant-to-wild-type ratio of activation times, to, and deactivation time constant, τd, determined as in materials and methods. Electrophysiological parameters are reported in Table .

Image published in: Hong KH and Miller C (2000)

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