Figure 15. Predicted GAT1 pre–steady state current transients. The voltage protocol is given below the figure. These model results are comparable to experimental results described previously (Lu and Hilgemann 1999b). (A) Outward current condition without extracellular Na+: 120 mM cytoplasmic NaCl, 20 mM cytoplasmic GABA, and 20 mM extracellular Cl−. (B) Outward current condition as in A with additional 120 mM extracellular Na+. (C) Inward current condition: 120 mM extracellular NaCl, 0.2 mM extracellular GABA, and no cytoplasmic substrates. (D) Charge movement condition: 120 mM extracellular NaCl and no other GAT1 substrates. (E) Current reversal condition: 120 mM NaCl and 2 mM GABA on the extracellular side; 120 mM Na+, 6 mM Cl−, and 2 mM GABA on the cytoplasmic side. See text for complete details.
Image published in: Hilgemann DW and Lu CC (1999)
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