Figure 4. Replacing the mSlo1 tail with the mSlo3 tail greatly decreases Ca2+ sensitivity and increases activity in the absence of Ca2+. (A) Single-channel currents recorded from a single mSlo1 tail channel and a single mSlo3 tail channel at different Ca2+i. Membrane potential: +30 mV. Currents were low-pass filtered at 8 kHz. (B and C) Plots of PO versus Ca2+i for four mSlo1 tail channels (B) and seven mSlo3 tail channels (C). The lines are fits of the Hill equation, with the mean values of the parameters given in the text. The mSlo1 tail and mSlo3 tail channels in A are represented by closed and open triangles, respectively, in B and C.
Image published in: Moss BL and Magleby KL (2001)
© 2001 The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license
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