Figure 1. . Small-conductance K+ channel run-down in a representative excised patch. In the cell-attached patch, inward K+ current was recorded showing five active SK channels. Since the pipette solution contained 140 mM KCl, the channel shows inward current displaying typical SK channel kinetics with high open probability. When the patch was excised into a 5 mM K+ bath solution, the current amplitude immediately decreased due to loss of the membrane potential. Then pipette holding potential (−Vpipette) was elevated from 0 to −40 mV, current amplitude was increased. SK channels completely closed in 1.7 min in the Ringer's solution after excision. The downward deflection of the traces shows inward current and the line “C” indicates the zero current level (channel completely closed state).
Image published in: Lu M et al. (2002)
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