Figure 1. . Schematic diagram of the membrane topology of the β1 and α subunit of the BK (Slo1) channel is shown in the top panel. The core and tail region of the α subunit are indicated as well as the RCK1, RCK2, and serine proteinase (SerP) like domains. The unconserved linker between S8 and S9 connects the core and tail as well as the two RCK domains. The tail contains the Ca2+ bowl with five consecutive aspartic acid residues, implicated with high affinity Ca2+ binding. Schematic diagrams of the channels examined in this study are indicated below the topology diagrams. Note that the linker region between the S8-S9 is missing in the Slo1 core/Slo3 tail channel, and is present in the Slo1 core/Slo3 tail joined channel.
Image published in: Qian X et al. (2002)
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