Figure 6. . In situ introduction of positive charge to the inner cavity decreases spermine-dependent rectification. (A) Representative currents illustrating rectification induced by spermine in WT-N160D dimer channels. Two voltage protocols are indicated. (B) Representative currents illustrating rectification induced by spermine in WT-N160D, and in V129C, L157C, and L164C mutant channels (mutation in second half of N160D-N160D dimer background), before and after complete modification by MTSEA+ (modification not shown). Voltage protocols as in A. Current scale indicates 0.5 nA in each case. (C) Steady-state current in spermine relative to control (Grel) plotted versus voltage, fitted with Boltzmann functions (no offset) as indicated.
Image published in: Kurata HT et al. (2004)
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