Figure 7. Proposed model for ssDNA oligo action. ssDNA oligos generated by MRN-dependent processing of DSBs stimulates ATM activity by forming MRN–DNA oligo complexes. Elimination of ssDNA oligos by single-stranded DNA exonucleases such as Trex1 (see Discussion) might indirectly control ATM activity.
Image published in: Jazayeri A et al. (2008)
Copyright © 2008, European Molecular Biology Organization. Creative Commons Attribution-NonCommercial-NoDerivatives license
Permanent Image Page
Printer Friendly View
XB-IMG-123121