Figure 8. Mechanical cell swelling activates an endogenous current in cytochalasin B-pretreated oocytes. ENaC-expressing oocytes responded by a transient increase of current at −100 mV 20 s after the 90-nl volume increase (A). However a similar response was observed in ENaC-expressing oocytes treated with 10 μM amiloride (B). This response was also observed in control oocytes (C ) and is, therefore, unrelated to the presence of ENaC. The initial stimulation is summarized at 20 s rather than 10 s, as this value was not measured in all groups of oocytes. However, the stimulation at 20 s was only slightly lower than that observed at 10 s. n = 7 for each group.
Image published in: Awayda MS and Subramanyam M (1998)
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