Figure 2. R878C mutation of SCN5A sodium channel. (a) Sequencing of SCN5A mutation: heterozygotic mutation C→T transition at nucleotide 2826. (b) Missense mutation of R878C. (c) Position of R878C on Nav1.5 channel. (d–e) Alignment analysis of Nav channel isoforms. R878 is a residue that is highly conserved in Nav channel isoforms (d) and among Scn5a in different rat, mouse and human species (e).
Image published in: Zhang Y et al. (2008)
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