Figure 11. Schematic model for the multiple mechanisms of CCB-inhibited transepithelial Na+ transport and recovery by K+ channels. CCB compounds alter Ca2+ signal most likely via modifying Ca2+ release from cytosolic compartments. In addition, CCB compounds directly regulate K+ channels, ENaC, and Na+/K+-ATPase. Disrupted basolateral K+ recycling and apical ion transport will abrogate transalveolar salt and fluid transport. K+ channel openers significantly restore the CCB-inhibited transepithelial Na+ transport by activating K+ channel, then facilitating Na+/K+-ATPase.
Image published in: Han DY et al. (2010)
Copyright ©2010 Han et al; licensee BioMed Central Ltd. Creative Commons Attribution license
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