Figure 4. Expression of bone morphogenic protein-4 (BMP-4; A,B), BMPR-IA (C), and Tolloid/BMP-1 (D) mRNA analyzed by in situ hybridization (ISH) with a digoxigenin (DIG) -labeled antisense RNA probe. A,B: BMP-4 mRNA reaches the maximum level around stage 62 in the connective tissue (CT). There is a gradient in its amount toward the adult epithelial primordia (P-AE; B). C,D: The level of BMPR-IA (C) and Tolloid/BMP-1 mRNA (D) is the highest around stage 61. BMPR-IA mRNA is weakly expressed in both the connective tissue and the adult epithelial primordia (arrowheads), but not in the larval epithelium (LE; C). In contrast, Tolloid/BMP-1 mRNA is expressed only in the connective tissue without a gradient (D). M, muscles. Scale bars = 20 mu m.
Image published in: Ishizuya-Oka A and Shi YB (2007)
Copyright © 2007. Image reproduced with permission of the Publisher, John Wiley & Sons.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| bmpr1a.S | acvrlk3, alk-3, alk3, cd292, skr5 | X. laevis | Throughout NF stage 62 | connective tissue splanchnic layer of lateral plate mesoderm mesenchyme intestine |
| bmp1.L | bmp-1, bmp1-a, bmp1-b, tld, tolloid, xbmp1, xtld | X. laevis | Throughout NF stage 62 | connective tissue intestine epithelium splanchnic layer of lateral plate mesoderm |
| bmp4.L | bmp2b, bmp2b1, bmp-4, bmp4-a, bmp4-b, DVR-4, ofc11, XBMP-4, xbmp4, zyme | X. laevis | Throughout NF stage 62 | connective tissue intestine splanchnic layer of lateral plate mesoderm mesenchyme |
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