Fig. 1. (A) Amino acid sequence comparison (single letter code) of the Xenopus laevis LAP2 (X) and LAP2b of Rattus norvegicus (R). The membrane spanning domain is underlined in the rat sequence. Bold printed letters represent amino acids identical in both proteins. Proteins contain 518 (X) and 452 (R) amino acids. Gaps (marked by dots) have been introduced in some areas of the sequences to allow their optimal alignement. The XLAP2 sequence has been published under accession no Y17861 in the EMBL Nucleotide Sequence Database. (B) Schematic drawings of rat LAP2b and Xenopus LAP2. Domains of XLAP2 that show a high degree of identiy with the chromatin/chromosome binding domain, the lamina/lamin B1/B2 binding domain, and the transmembrane domain (TM) of the rat LAP2b have been marked with the same patterns. The degree of identity between both molecules in these regions is given as a percentage (%) below XLAP2. Two XLAP2 domains not contained in the rat protein are marked in black. The positions of individual amino acids has been marked on top of each molecule.
Image published in: Lang C et al. (1999)
Copyright © 1999. Image reproduced with permission of the Publisher, The Company of Biologists Ltd.
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