Fig 1. Expression of nol11 during vertebrate development. A) Wild type nol11 expression pattern during Xenopus tropicalis development. Note the strong expression in developing neural folds (NF) and the presumptive CNC at stages 16 and 22 (lateral [left] and dorsal [right] views presented). Expression is strongly associated with the migrating and differentiating CNC at subsequent stages, and is also detected in the region of the ventral blood islands (BI) and isthmus (Is) at stage 28. BA, branchial arch; Ht, heart; Lv, liver region; Op, optic placode. B) and C) Anterior transverse dissections showing expression of nol11 in neural folds and premigratory CNC of stage 14 and 16 embryos respectively. Plane of dissection is represented by the red dotted line marked c in A. D) Horizontal dissection (shown as dotted red line marked d in A) of nol11 expression in the branchial arches of stage 28 Xenopus embryos. E) nol11 expression in E8.5, E9.5 and E10.5 wild type mouse embryos. At E8.5 expression is strongly detected in the neural folds. Transcripts are associated with CNC positive regions at both E9.5 and E10.5. BA2, 2nd branchial arch; FNP, frontonasal prominence; Ht, heart; mdBA1, mandibular BA1; mxBA1, maxillary BA1; Op, optic placode; Ot, otic placode; T, trigeminal region. doi:10.1371/journal.pgen.1005018.g001
Image published in: Griffin JN et al. (2015)
Image reproduced on Xenbase with permission of the publisher and the copyright holder. Creative Commons Attribution license
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| nol11 | X. tropicalis | Throughout NF stage 16 | neural crest trunk neural crest cranial neural crest | |
| nol11 | X. tropicalis | Throughout NF stage 22 | neural crest cranial neural crest trunk neural crest hyoid crest mandibular crest | |
| nol11 | X. tropicalis | Throughout NF stage 26 | neural crest cranial neural crest migratory neural crest cell hyoid crest mandibular crest | |
| nol11 | X. tropicalis | Throughout NF stage 28 | neural crest cranial neural crest branchial arch ventral blood island midbrain-hindbrain boundary isthmic nucleus |
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