Fig. 3. Mutation of the C-clamp of XTcf-1E leads to a loss of isoform specificity. (A) XTcf1E-CRVRF holds a mutation in the C-clamp changing alanine into valine in the CR1 motif. XTcf1-deltaC has a premature stop codon directly 3â of the NLS. (B) Injection of 400 pg mRNA XTcf1- CRVRF induced ectopic dorsal mesoderm as indicated by the expansion of Chordin expression at the gastrula stage as does XTcf1-deltaC. (C,D) XTcf1E-CRVRF induces double axis formation in 29% of the injected embryos.
Image published in: Roël G et al. (2017)
Copyright © 2017. Image reproduced with permission of the Publisher, University of the Basque Country Press.
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