Figure 7. Xenopus laevis cardiac repair shares elements of the mammalian stress response and the urodele/fish regenerative response. (a) The cardiac response of X. laevis tadpoles to oxidative stress shares elements with the stereotyped cardiac regeneration response, but each pathway also contains unique mechanisms not shared by the other. (b) The X. laevis cardiac repair response can be divided into two phases, a stress phase dominated by ventricular hypertrophy and upregulation of Hsp70, and a repair‐like phase dominated by re‐expression of cardiac development genes and cardiomyocyte proliferation
Image published in: Jewhurst K and McLaughlin KA (2019)
Copyright © 2019. Image reproduced with permission of the Publisher, John Wiley & Sons.
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