Larger Image Fig 3 RAR-selective agonist TTNPB modulates expression of genes identified by RNA-seq. (A-P) WISH from embryos treated at stage 6/7 with 1†μM TTNPB or control vehicle (0.1% ethanol). (A-D,I-L) Control expression of znf703, znf503, kremen2, mamdc2, skida1, nkx6-2, dhh and cyp26a1. (E-H,M-P) TTNPB expands expression of these genes. All embryos are shown in vegetal view at stage 10.5/11 with dorsal lip at the top. N, number of embryos scored in the experiment; 100% of embryos displayed the phenotype shown. Image published in: Janesick A et al. (2018) Copyright © 2018. Image reproduced with permission of the Publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue znf703.L znf703-a, znf703-b X. laevis Sometime during NF stage 10.5 to NF stage 11 mesoderm dorso-lateral marginal zone ventro-lateral marginal zone ventral marginal zone znf503.L LOC108703372, LOC108703986 X. laevis Sometime during NF stage 10.5 to NF stage 11 ventral marginal zone ventro-lateral marginal zone dorso-lateral marginal zone kremen2.S kremen 2, krm2 X. laevis Sometime during NF stage 10.5 to NF stage 11 ventral marginal zone ventro-lateral marginal zone dorso-lateral marginal zone mamdc2.L gene B, geneb, MAM domain protein X. laevis Sometime during NF stage 10.5 to NF stage 11 ventral marginal zone ventro-lateral marginal zone dorso-lateral marginal zone nkx6-2.L nkx6.2 X. laevis Sometime during NF stage 10.5 to NF stage 11 dorsal marginal zone upper blastopore lip dhh.L cephalic hedgehog, chh, desert hedgehog, dhh-1, dhh-a, dhh-b, x-chh, Xchh X. laevis Sometime during NF stage 10.5 to NF stage 11 marginal zone blastopore lip cyp26a1.S cyp26, RACE, retinoic acid converting enzyme, xCYP26, XCYP26A1 X. laevis Sometime during NF stage 10.5 to NF stage 11 circumblastoporal collar mesoderm Image source: Published Permanent Image Page Printer Friendly View XB-IMG-177049