Fig. 1. Effects of citral and BMS-453 on pronephros marker genes. Embryos were incubated during gastrulation with citral (B, E) or BMS-453 (C, F) or cultured in control medium (A, D). At the late tailbud stage 33, XSMP-30 (AâC) and XPax-2 (DâF) expression was analysed by whole mount in situ hybridization. Panels Dâ², Eâ², Fâ² are high magnification of the pronephric tubules area of panels D, E, F, respectively. XSMP-30 expression is severely reduced in embryos treated with the chemical inhibitors (B, C). XPax-2 expression in connective tubules and nephrostomes (arrowheads in panel Dâ²) is lost in treated embryos (Eâ², Fâ²) while expression in the duct is not affected.
Image published in: Cartry J et al. (2006)
Copyright © 2006. Image reproduced with permission of the Publisher, Elsevier B. V.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| rgn.L | regucalcin, smp30, xsmp-30, xsmp30 | X. laevis | Throughout NF stage 33 and 34 | pronephric kidney |
| pax2.L | LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 | X. laevis | Throughout NF stage 33 and 34 | tail bud eye pharyngeal arch cement gland spinal cord pronephric kidney pronephric tubule pronephric nephrostome pronephric duct brain |
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