Figure 4. Cardiac gene expression at stage 41 by in situ hybridization on section. Transverse and sagittal sections are at the level of the OFT and AV canal, respectively. A, J: Hematoxylin/eosin (H-E) stained sections. Bmp4 (B, K), Msx1 (C, L), and Nkx2.5 (D, M) are expressed in the myocardium. Frzb1 (E, N), Sox8 (F, O), Sox9 (G, P), and Xl-Fli (I, R) are expressed in the mesenchyme of the OFT and AV cushions. Sox10 (H, Q) is weakly expressed in the OFT mesenchyme. AV, atrioventricular cushion; L, liver; OFT, outflow tract cushion; V, ventricle. Scale bar = 50 mu m.
Image published in: Lee YH and Saint-Jeannet JP (2009)
Copyright © 2009. Image reproduced with permission of the Publisher, John Wiley & Sons.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| sox10.L | X. laevis | Throughout NF stage 39 | heart mesenchyme | |
| bmp4.L | bmp2b, bmp2b1, bmp-4, bmp4-a, bmp4-b, DVR-4, ofc11, XBMP-4, xbmp4, zyme | X. laevis | Throughout NF stage 41 | heart myocardium |
| nkx2-5.L | AR2, csx, nkx-2.5, Nkx-2.5, nkx2.5, nkx2-5-a, nkx2-5-b, tinman, XNkx-2.5, XNkx2-5 | X. laevis | Throughout NF stage 41 | heart myocardium |
| msx1.L | hox-7, hox7, msx-1, msx1-a, msx1-b, Xhox-7.1, Xmsx-1, xmsx1 | X. laevis | Throughout NF stage 41 | heart myocardium |
| sox8.L | X. laevis | Throughout NF stage 41 | heart mesenchyme | |
| frzb.S | fiz, fre, frp-3, Frzb-1, frzb1, frzb-pen, fzrb, os1, sfrp3, srfp3, xfrzb | X. laevis | Throughout NF stage 41 | heart mesenchyme |
| sox9.S | cmd1, cmpd1, sox-9, sox9-a, sox9-b, sra1 | X. laevis | Throughout NF stage 41 | heart mesenchyme |
| fli1.S | fli, fli-1, fli1-a, Xfli, Xfli-1, Xfli1 | X. laevis | Throughout NF stage 41 | heart mesenchyme |
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