Fig. 1. Shroom3 is essential for morphogenesis of the developing Xenopus gut. (A) The expression pattern of Shroom3 in a normal stage 43 dissected gut. Shroom3 is robustly expressed in the foregut (arrow). (B,Bâ²) Normal gut looping in a control stage 46 embryo injected with mRNA encoding GFP only (green in Bâ²). (C,Câ²) Gut looping is disrupted following dominant-negative (DN)-Shroom3 expression (as marked by GFP, green in Câ²). (D,E) Control gut (D) and DN-Shroom3-injected (E) gut epithelium. GFP-positive gut epithelial cells display a high-columnar morphology in controls, whereas cells expressing GFP and DN-Shroom3 display more rounded shapes.
Image published in: Chung MI et al. (2010)
Copyright © 2010. Image reproduced with permission of the Publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| shroom3.L | apxl3, LOC108706772, shrm, shroom, shroom-like, xshroom3 | X. laevis | Throughout NF stage 43 | foregut hindgut gut epithelium |
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