FIG. 1. Comparison of expression of Xenopus tinman homologues. Tail bud embryos were stained in whole mount for the expression of the three Xenopus tinman homologues (stage 22, A; stage 24, D; stage 27/29, G) along with tadpoles at the linear heart tube stage (stage 30/32, J) and at the onset of chamber formation (stage 38/40, L, M). XNkx2-5 is shown in A, D, G, J, and M; XNkx2-3 in B, E, H, K and N; and XNkx2-10 in C, F, I, and L. In all cases lateral views are shown with anterior to the left. In (D) a black arrow indicates where the XNkx2-5 expression in the endoderm begins to be partially occluded by neural crest. FIG. 2. Comparison of expression of Xenopus tinman homologues. Ventral views of the same embryos depicted in Fig. 1. In all cases anterior is to the left.
Image published in: Sparrow DB et al. (2000)
Copyright © 2000. Image reproduced with permission of the Publisher, Elsevier B. V.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| nkx2-5.L | AR2, csx, nkx-2.5, Nkx-2.5, nkx2.5, nkx2-5-a, nkx2-5-b, tinman, XNkx-2.5, XNkx2-5 | X. laevis | Throughout NF stage 22 | endoderm mesoderm primary heart field secondary heart field foregut |
| nkx2-3.S | nkx-2.3, nkx2.3, nkx2-3-a, nkx2-3-b, xnkx-2.3, xnkx2-3 | X. laevis | Throughout NF stage 22 | endoderm mesoderm cardiac mesoderm secondary heart field cement gland |
| nkx2-6.L | nkx2.6, tix, Xnkx2-10 | X. laevis | Throughout NF stage 22 | endoderm mesoderm cardiac mesoderm |
| nkx2-5.L | AR2, csx, nkx-2.5, Nkx-2.5, nkx2.5, nkx2-5-a, nkx2-5-b, tinman, XNkx-2.5, XNkx2-5 | X. laevis | Throughout NF stage 24 | endoderm mesoderm heart primary heart field secondary heart field foregut pharynx |
| nkx2-3.S | nkx-2.3, nkx2.3, nkx2-3-a, nkx2-3-b, xnkx-2.3, xnkx2-3 | X. laevis | Throughout NF stage 24 | endoderm mesoderm primary heart field secondary heart field foregut |
| nkx2-6.L | nkx2.6, tix, Xnkx2-10 | X. laevis | Throughout NF stage 24 | endoderm mesoderm cardiac mesoderm primary heart field secondary heart field |
| nkx2-5.L | AR2, csx, nkx-2.5, Nkx-2.5, nkx2.5, nkx2-5-a, nkx2-5-b, tinman, XNkx-2.5, XNkx2-5 | X. laevis | Sometime during NF stage 27 to NF stage 29 and 30 | endoderm mesoderm primary heart field secondary heart field foregut pharynx myocardium |
| nkx2-3.S | nkx-2.3, nkx2.3, nkx2-3-a, nkx2-3-b, xnkx-2.3, xnkx2-3 | X. laevis | Sometime during NF stage 27 to NF stage 29 and 30 | endoderm mesoderm heart cardiac mesoderm primary heart field secondary heart field foregut myocardium mouth primordium eye brain pharynx mesenchyme |
| nkx2-6.L | nkx2.6, tix, Xnkx2-10 | X. laevis | Sometime during NF stage 27 to NF stage 29 and 30 | endoderm mesoderm heart cardiac mesoderm foregut |
| nkx2-5.L | AR2, csx, nkx-2.5, Nkx-2.5, nkx2.5, nkx2-5-a, nkx2-5-b, tinman, XNkx-2.5, XNkx2-5 | X. laevis | Sometime during NF stage 29 and 30 to NF stage 32 | endoderm mesoderm heart primary heart field secondary heart field foregut pharynx myocardium |
| nkx2-3.S | nkx-2.3, nkx2.3, nkx2-3-a, nkx2-3-b, xnkx-2.3, xnkx2-3 | X. laevis | Sometime during NF stage 29 and 30 to NF stage 32 | endoderm mesoderm heart cardiac mesoderm primary heart field secondary heart field myocardium pharynx mesenchyme mouth primordium |
| nkx2-6.L | nkx2.6, tix, Xnkx2-10 | X. laevis | Sometime during NF stage 29 and 30 to NF stage 32 | endoderm mesoderm foregut cement gland |
| nkx2-5.L | AR2, csx, nkx-2.5, Nkx-2.5, nkx2.5, nkx2-5-a, nkx2-5-b, tinman, XNkx-2.5, XNkx2-5 | X. laevis | Sometime during NF stage 37 and 38 to NF stage 40 | mesoderm heart cardiac mesoderm outflow tract ventricular outflow tract ventral pharynx endoderm |
| nkx2-3.S | nkx-2.3, nkx2.3, nkx2-3-a, nkx2-3-b, xnkx-2.3, xnkx2-3 | X. laevis | Sometime during NF stage 37 and 38 to NF stage 40 | foregut mouth primordium pharynx |
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