Fig. 3. Fgf signalling is required for the initiation of heart specification. Expression of both nkx2.5 and isl1 is readily detectable in the cardiac crescent of stage 20 embryos (A and C). Embryos treated with SU5402 to inhibit fgfr1 activity show a loss of nkx2.5 expression (B), and a down regulation of isl1 expression (D). In both cases, the anterior pole of the embryo is viewed, with dorsal folds visible toward the top of the image. The total number of embryos examined for each panel is indicated in the lower left hand corner.
Image published in: Deimling SJ and Drysdale TA (2011)
Copyright © 2011. Image reproduced with permission of the Publisher, Elsevier B. V.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| nkx2-5.L | AR2, csx, nkx-2.5, Nkx-2.5, nkx2.5, nkx2-5-a, nkx2-5-b, tinman, XNkx-2.5, XNkx2-5 | X. laevis | Throughout NF stage 20 | cardiac mesoderm |
| isl1.S | islet-1, islet1, Xisl-1, Xislet-1 | X. laevis | Throughout NF stage 20 | cardiac mesoderm cardiac neural crest |
Image source: Published
| Experiment + Assay | Source | Phenotypes and Disease | ||
|---|---|---|---|---|
| Xla Wt + su5402 (@12.5) + NF20 (in situ hybridization) | Fig. 3 BD |
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