Fig. S3. Depletion of Lrig3 by L3MO inhibited NC formation. Embryos were injected with 15 ng L3MO into one dorsal blastomere at the four-cell stage. The expression of the retinal marker Rx2A (A-A′′) and the NC markers Ap2a (B-B′′), Traf4 (C-C′′) and Twist (D-D′′) was examined at the late neurula stage; the injection side was visualized by lacZ staining. Rx2a was modestly decreased on the injected side (48%, 13 of 27 embryos). Traf4 (80%, 16 of 20), Twist (83%, 25 of 30), and Ap2a (80%, 16 of 20) were strongly inhibited.
Image published in: Zhao H et al. (2008)
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