FIGURE 4 Hypothesis driven drug testing in genetically engineered Xenopus tropicalis tumor models. Straightforward delivery of targeted nucleases (CRISPR/Cas9, TALEN) within the extrauterine developing Xenopus tropicalis embryo allows for generation of large cohorts (1100 animals) of tumor-bearing GEXM. Tumor-bearing GEXM can be directly subjected to drug treatment, by being reared in water with added compound. Subsequently, the tumor responses can be analyzed in large cohorts adding power to statistical analyses
Image published in: Naert T et al. (2017)
Copyright © 2017. Image reproduced with permission of the Publisher, John Wiley & Sons.
Permanent Image Page
Printer Friendly View
XB-IMG-156030