Fig. S2 (related to Fig. 2). Assessment of the effects of KDM3A depletion on neural development. (A, B, C) Control (cMO) and KDM3A morphant (3A MO) embryos at stage 18in situ hybridized with indicated marker genes. (A) Neuronal genes. (B) Markers for neural progenitors (sox3, pax6) and the anteroposterior pattern (rx, krox20, en2, and hoxb9). (C) Markers for neural plate border, neural crest specification and epidermis. (D) Dorsal view of embryos at stage 18 showing that KDM3A depletion by injecting 60 ng 3A MO delays neural tube closure, which was partially rescued by injecting back of 500 pg the MO-resistant kdm3a mRNA.
Image published in: Lin H et al. (2017)
Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| neurod1.L | neurod, neuroD, neurod1-a, neurod1-b, XNeuroD | X. laevis | Throughout NF stage 18 | neuron neurogenic placode |
| myt1.L | X-MyT1, xmyt1, XMyTI | X. laevis | Throughout NF stage 18 | neuron neural plate |
| isl1.L | islet-1, islet1, Xisl-1, Xislet-1 | X. laevis | Throughout NF stage 18 | neuron neural plate |
| mnx1.L | hb9, hlxb9, hoxhb9, scra1 | X. laevis | Throughout NF stage 18 | neural plate |
| mnx1.L | hb9, hlxb9, hoxhb9, scra1 | X. laevis | Throughout NF stage 18 | neurogenic placode neuron |
| sox3.L | Sry, Xlsox3, xSox3, Xtsox3 | X. laevis | Throughout NF stage 18 | neural plate preplacodal ectoderm |
| pax6.L | an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 | X. laevis | Throughout NF stage 18 | neural plate optic vesicle |
| pax6.L | an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 | X. laevis | Throughout NF stage 18 | neural plate optic vesicle |
| rax.L | rax-a, rax-b, rax1, rx, rx-1, rx1, rx1a, Rx2A, Xrax, Xrx1, Xrx1A | X. laevis | Throughout NF stage 18 | eye primordium |
| egr2.L | EGR-2, Krox-20, krox20, XKr20, XKrox-20 | X. laevis | Throughout NF stage 18 | presumptive rhombomere cranial neural crest |
| en2.L | En-2, en2-a, en2-b, eng2, engrailed 2, engrailed homolog 2, engrailed-2, maben, xen2 | X. laevis | Throughout NF stage 18 | presumptive midbrain-hindbrain boundary |
| hoxb9.L | hox 2.5, xhoxb9, XlHbox-6, XlHbox6 | X. laevis | Throughout NF stage 18 | posterior neural tube |
| sox9.L | cmd1, cmpd1, sox-9, sox9-a, sox9-b, sra1 | X. laevis | Throughout NF stage 18 | neural crest neural plate border |
| snai1.L | LOC108702592, sna, snail, snail1, xSna, Xsnail | X. laevis | Throughout NF stage 18 | epidermis neural plate border neural crest |
| msx1.L | hox-7, hox7, msx-1, msx1-a, msx1-b, Xhox-7.1, Xmsx-1, xmsx1 | X. laevis | Throughout NF stage 18 | neural crest neural plate neural fold |
| zic1.L | odd-paired-like, opl, Zic-r1, Zic-related-1 | X. laevis | Throughout NF stage 18 | neural plate neural crest neural plate border |
| krt12.5.L | krt12, krt12.1, larval keratin, xk81b2 | X. laevis | Throughout NF stage 18 | epidermis |
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